Research output: Contribution to journal › Review article › peer-review
Journal | Nature Communications |
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Date | Published - 5 Sep 2014 |
Volume | 5 |
Number of pages | 14 |
Original language | English |
Chemical modification of proteins is an important tool for probing natural systems, creating therapeutic conjugates and generating novel protein constructs. Site-selective reactions require exquisite control over both chemo- and regioselectivity, under ambient, aqueous conditions. There are now various methods for achieving selective modification of both natural and unnatural amino acids - each with merits and limitations - providing a toolkit that until 20 years ago was largely limited to reactions at nucleophilic cysteine and lysine residues. If applied in a biologically benign manner, this chemistry could form the basis of true Synthetic Biology.
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