Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

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Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N-acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.

Original languageEnglish
Pages (from-to)7527-7532
Number of pages6
JournalOrganic and Biomolecular Chemistry
Publication statusPublished - 5 Sept 2017

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