Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

James A Rossi-Ashton; Richard J K Taylor; William P Unsworth

doi:10.1039/c7ob02039b

Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

James A Rossi-Ashton, Richard J K Taylor, William P Unsworth

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N-acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.

Original language	English
Pages (from-to)	7527-7532
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	15
DOIs	https://doi.org/10.1039/c7ob02039b
Publication status	Published - 5 Sept 2017

Bibliographical note

© The Royal Society of Chemistry 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

Keywords

Journal Article

Access to Document

10.1039/c7ob02039b

Rossi Trimer paper OBC
© The Royal Society of Chemistry 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Accepted author manuscript, 3.84 MB

Cite this

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abstract = "Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N-acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.",

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