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Self-Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver Nanoparticles for Antimicrobial Application

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JournalChemistry : A European Journal
DateAccepted/In press - 15 Apr 2020
DateE-pub ahead of print (current) - 15 Apr 2020
Number of pages6
Pages (from-to)8452-8457
Early online date15/04/20
Original languageEnglish


This paper reports the formation of silver (Ag) NPs within spatially-resolved two-component hydrogel beads that combine a low-molecular-weight gelator (LMWG) DBS-CONHNH2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed via in situ reduction of Ag(I), with the resulting nanoparticle-loaded gels being characterised in detail. We tested the antibacterial activity of the nanocomposite gel beads against two drug-resistant bacterial strains, often associated with hospital-acquired infections: vancomycin-resistant Enterococcus faecium (VRE) and Pseudomonas aeruginosa (PA14), and the AgNP-loaded gels showed good antimicrobial properties against both types of bacteria. We suggest that the gel bead format of these AgNP-loaded hybrid hydrogels makes them promising versatile materials for potential applications in orthopaedics or wound healing.

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© 2020 WILEY‐VCH Verlag GmbH & Co. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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