Serum beta 2-microglobulin and human immunodeficiency virus infection

M A Forbes, M A Waugh, E H Cooper, M H Hambling, Charles John Nash Lacey

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Serum beta 2-microglobulin (beta 2-M) was measured in two prospectively evaluated groups of homosexual men in 1983 and 1985. Serum beta 2-M was raised in 64% of patients with HIV infection, but in only 6.7% of uninfected homosexuals. Depression of the total lymphocyte count was only clinically useful when it reached less than 1.0 X 10(9)/l. In further studies all patients with AIDS and AIDS-related complex (ARC) had raised levels of serum beta 2-M. Mean levels of beta 2-M did not differ between patients with persistent generalized lymphadenopathy (PGL) and asymptomatic HIV-infected patients. Raised serum levels of beta 2-M accompanied major immune dysfunction in HIV infection. Serum beta 2-M levels of greater than 3.0 mg/l in HIV-infected homosexual men were associated with progression to AIDS.
Original languageEnglish
Pages (from-to)123-7
Number of pages5
Issue number2
Publication statusPublished - 1987


  • Acquired Immunodeficiency Syndrome
  • Adolescent
  • Adult
  • Antibodies, Viral
  • HIV
  • HIV Antibodies
  • Homosexuality
  • Humans
  • Leukocyte Count
  • Lymphocytes
  • Male
  • Middle Aged
  • Prognosis
  • beta 2-Microglobulin

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