Serum beta 2-microglobulin and human immunodeficiency virus infection

M A Forbes; M A Waugh; E H Cooper; M H Hambling; Charles John Nash Lacey

Serum beta 2-microglobulin and human immunodeficiency virus infection

M A Forbes, M A Waugh, E H Cooper, M H Hambling, Charles John Nash Lacey

The Hull York Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Serum beta 2-microglobulin (beta 2-M) was measured in two prospectively evaluated groups of homosexual men in 1983 and 1985. Serum beta 2-M was raised in 64% of patients with HIV infection, but in only 6.7% of uninfected homosexuals. Depression of the total lymphocyte count was only clinically useful when it reached less than 1.0 X 10(9)/l. In further studies all patients with AIDS and AIDS-related complex (ARC) had raised levels of serum beta 2-M. Mean levels of beta 2-M did not differ between patients with persistent generalized lymphadenopathy (PGL) and asymptomatic HIV-infected patients. Raised serum levels of beta 2-M accompanied major immune dysfunction in HIV infection. Serum beta 2-M levels of greater than 3.0 mg/l in HIV-infected homosexual men were associated with progression to AIDS.

Original language	English
Pages (from-to)	123-7
Number of pages	5
Journal	Aids
Volume	1
Issue number	2
Publication status	Published - 1987

Keywords

Acquired Immunodeficiency Syndrome
Adolescent
Adult
Antibodies, Viral
HIV
HIV Antibodies
Homosexuality
Humans
Leukocyte Count
Lymphocytes
Male
Middle Aged
Prognosis
beta 2-Microglobulin

Cite this

@article{cb09247bccb849e8aea19d2750379ccb,

title = "Serum beta 2-microglobulin and human immunodeficiency virus infection",

abstract = "Serum beta 2-microglobulin (beta 2-M) was measured in two prospectively evaluated groups of homosexual men in 1983 and 1985. Serum beta 2-M was raised in 64% of patients with HIV infection, but in only 6.7% of uninfected homosexuals. Depression of the total lymphocyte count was only clinically useful when it reached less than 1.0 X 10(9)/l. In further studies all patients with AIDS and AIDS-related complex (ARC) had raised levels of serum beta 2-M. Mean levels of beta 2-M did not differ between patients with persistent generalized lymphadenopathy (PGL) and asymptomatic HIV-infected patients. Raised serum levels of beta 2-M accompanied major immune dysfunction in HIV infection. Serum beta 2-M levels of greater than 3.0 mg/l in HIV-infected homosexual men were associated with progression to AIDS.",

keywords = "Acquired Immunodeficiency Syndrome, Adolescent, Adult, Antibodies, Viral, HIV, HIV Antibodies, Homosexuality, Humans, Leukocyte Count, Lymphocytes, Male, Middle Aged, Prognosis, beta 2-Microglobulin",

author = "Forbes, {M A} and Waugh, {M A} and Cooper, {E H} and Hambling, {M H} and Lacey, {Charles John Nash}",

year = "1987",

language = "English",

volume = "1",

pages = "123--7",

journal = "Aids",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Serum beta 2-microglobulin and human immunodeficiency virus infection

AU - Forbes, M A

AU - Waugh, M A

AU - Cooper, E H

AU - Hambling, M H

AU - Lacey, Charles John Nash

PY - 1987

Y1 - 1987

N2 - Serum beta 2-microglobulin (beta 2-M) was measured in two prospectively evaluated groups of homosexual men in 1983 and 1985. Serum beta 2-M was raised in 64% of patients with HIV infection, but in only 6.7% of uninfected homosexuals. Depression of the total lymphocyte count was only clinically useful when it reached less than 1.0 X 10(9)/l. In further studies all patients with AIDS and AIDS-related complex (ARC) had raised levels of serum beta 2-M. Mean levels of beta 2-M did not differ between patients with persistent generalized lymphadenopathy (PGL) and asymptomatic HIV-infected patients. Raised serum levels of beta 2-M accompanied major immune dysfunction in HIV infection. Serum beta 2-M levels of greater than 3.0 mg/l in HIV-infected homosexual men were associated with progression to AIDS.

AB - Serum beta 2-microglobulin (beta 2-M) was measured in two prospectively evaluated groups of homosexual men in 1983 and 1985. Serum beta 2-M was raised in 64% of patients with HIV infection, but in only 6.7% of uninfected homosexuals. Depression of the total lymphocyte count was only clinically useful when it reached less than 1.0 X 10(9)/l. In further studies all patients with AIDS and AIDS-related complex (ARC) had raised levels of serum beta 2-M. Mean levels of beta 2-M did not differ between patients with persistent generalized lymphadenopathy (PGL) and asymptomatic HIV-infected patients. Raised serum levels of beta 2-M accompanied major immune dysfunction in HIV infection. Serum beta 2-M levels of greater than 3.0 mg/l in HIV-infected homosexual men were associated with progression to AIDS.

KW - Acquired Immunodeficiency Syndrome

KW - Adolescent

KW - Adult

KW - Antibodies, Viral

KW - HIV

KW - HIV Antibodies

KW - Homosexuality

KW - Humans

KW - Leukocyte Count

KW - Lymphocytes

KW - Male

KW - Middle Aged

KW - Prognosis

KW - beta 2-Microglobulin

M3 - Article

C2 - 3130078

SN - 0269-9370

VL - 1

SP - 123

EP - 127

JO - Aids

JF - Aids

IS - 2

ER -