Projects per year
Abstract
Hydrogels with spatio-temporally controlled properties are appealing materials for biological and pharmaceutical applications. We make use of mild acidification protocols to fabricate hybrid gels using calcium alginate in the presence of a pre-formed thermally-triggered gel based on a low-molecular-weight gelator (LMWG) 1,3:2:4-di(4-acylhydrazide)-benzylidene sorbitol (DBS-CONHNH2). Non-water soluble calcium carbonate slowly releases calcium ions over time when exposed to acidic pH, triggering the assembly of the calcium alginate gel network. We combined the gelators in different ways: (i) the LMWG was used as a template to spatially control slow calcium alginate gelation within pre-formed gel beads, using glucono--lactone (GdL) to lower the pH; (ii) the LMWG was used as a template to spatially control slow calcium alginate gelation within pre-formed gel trays, using diphenylidonium nitrate (DPIN) as a photo-acid to lower the pH, and spatial resolution achieved by masking. The dual-network hybrid gels display highly tuneable properties and the beads are compatible with stem cell growth. Furthermore, they preserve the LMWG function of inducing in situ silver nanoparticle (AgNP) formation, which provides the gels with antibacterial activity. These gels have potential for eventual regenerative medicine applications in (e.g.) bone tissue engineering.
Original language | English |
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Pages (from-to) | 1829-1840 |
Journal | ACS Biomaterials Science & Engineering |
Volume | 8 |
Issue number | 5 |
Early online date | 2 Apr 2022 |
DOIs | |
Publication status | Published - 9 May 2022 |
Bibliographical note
© 2022 The Authors.Projects
- 2 Finished
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UKRI CoA Extension to R1897101 Multi-Domain Self-Assembled Gels: From Multi-Component Materials to Spatial and Temporal Control of Multi-component Biology
1/02/21 → 30/04/21
Project: Research project (funded) › Research
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Multi-Domain Self-Assembled Gels: From Multi-Component Materials to Spatial and Temporal Control of Multi-component Biology
1/12/17 → 31/01/21
Project: Research project (funded) › Research