Daniel James Raines, Thomas James Sanderson, A-K Duhme-Klair, Ellis Wilde

Research output: Chapter in Book/Report/Conference proceedingChapter


Siderophores are small molecules that are produced and secreted by micro-organisms in order to mediate the uptake of essential Fe(III) into the cell. This chapter provides a concise overview of siderophores, their chemistry and importance in nature, synthetic siderophore mimics, derivatives and their applications. Since the competition for Fe(III) requires micro-organisms to continuously evolve their uptake pathways, new siderophores are continually being discovered. A description of the chemical design features of siderophores and their coordination chemistry is followed by examples chosen to illustrate their chemical synthesis and biosynthesis. Recent insights into siderophore-mediated iron uptake and the proteins involved in the process are summarized for both Gram-negative and Gram-positive bacteria. It is then illustrated how high-affinity Fe(III)-chelators can be exploited in the design of Trojan horse antibiotics, the treatment of iron overload and the development fluorescent chemosensors.
Original languageEnglish
Title of host publicationElsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Place of PublicationWaltham
Number of pages33
ISBN (Print)978-0-12-409547-2
Publication statusPublished - 23 Jan 2015


  • Siderophores, iron chelation, ferric iron, iron uptake, iron transport, siderophore mimics, siderophore derivatives, siderophore receptors, periplasmic binding proteins, Trojan horse antimicrobials, iron overload, fluorescent sensors

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