Siderophores

TY - CHAP

T1 - Siderophores

AU - Raines, Daniel James

AU - Sanderson, Thomas James

AU - Duhme-Klair, A-K

AU - Wilde, Ellis

PY - 2015/1/23

Y1 - 2015/1/23

N2 - Siderophores are small molecules that are produced and secreted by micro-organisms in order to mediate the uptake of essential Fe(III) into the cell. This chapter provides a concise overview of siderophores, their chemistry and importance in nature, synthetic siderophore mimics, derivatives and their applications. Since the competition for Fe(III) requires micro-organisms to continuously evolve their uptake pathways, new siderophores are continually being discovered. A description of the chemical design features of siderophores and their coordination chemistry is followed by examples chosen to illustrate their chemical synthesis and biosynthesis. Recent insights into siderophore-mediated iron uptake and the proteins involved in the process are summarized for both Gram-negative and Gram-positive bacteria. It is then illustrated how high-affinity Fe(III)-chelators can be exploited in the design of Trojan horse antibiotics, the treatment of iron overload and the development fluorescent chemosensors.

AB - Siderophores are small molecules that are produced and secreted by micro-organisms in order to mediate the uptake of essential Fe(III) into the cell. This chapter provides a concise overview of siderophores, their chemistry and importance in nature, synthetic siderophore mimics, derivatives and their applications. Since the competition for Fe(III) requires micro-organisms to continuously evolve their uptake pathways, new siderophores are continually being discovered. A description of the chemical design features of siderophores and their coordination chemistry is followed by examples chosen to illustrate their chemical synthesis and biosynthesis. Recent insights into siderophore-mediated iron uptake and the proteins involved in the process are summarized for both Gram-negative and Gram-positive bacteria. It is then illustrated how high-affinity Fe(III)-chelators can be exploited in the design of Trojan horse antibiotics, the treatment of iron overload and the development fluorescent chemosensors.

KW - Siderophores, iron chelation, ferric iron, iron uptake, iron transport, siderophore mimics, siderophore derivatives, siderophore receptors, periplasmic binding proteins, Trojan horse antimicrobials, iron overload, fluorescent sensors

U2 - 10.1016/B978-0-12-409547-2.11040-6

DO - 10.1016/B978-0-12-409547-2.11040-6

M3 - Chapter

SN - 978-0-12-409547-2

BT - Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

PB - Elsevier

CY - Waltham

ER -