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Siderophores

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Publication details

Title of host publicationElsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
DatePublished - 23 Jan 2015
Number of pages33
PublisherElsevier
Place of PublicationWaltham
Original languageEnglish
ISBN (Print)978-0-12-409547-2

Abstract

Siderophores are small molecules that are produced and secreted by micro-organisms in order to mediate the uptake of essential Fe(III) into the cell. This chapter provides a concise overview of siderophores, their chemistry and importance in nature, synthetic siderophore mimics, derivatives and their applications. Since the competition for Fe(III) requires micro-organisms to continuously evolve their uptake pathways, new siderophores are continually being discovered. A description of the chemical design features of siderophores and their coordination chemistry is followed by examples chosen to illustrate their chemical synthesis and biosynthesis. Recent insights into siderophore-mediated iron uptake and the proteins involved in the process are summarized for both Gram-negative and Gram-positive bacteria. It is then illustrated how high-affinity Fe(III)-chelators can be exploited in the design of Trojan horse antibiotics, the treatment of iron overload and the development fluorescent chemosensors.

    Research areas

  • Siderophores, iron chelation, ferric iron, iron uptake, iron transport, siderophore mimics, siderophore derivatives, siderophore receptors, periplasmic binding proteins, Trojan horse antimicrobials, iron overload, fluorescent sensors

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