Signal Amplification by Reversible Exchange (SABRE): From Discovery to Diagnosis

TY - JOUR

T1 - Signal Amplification by Reversible Exchange (SABRE):

T2 - From Discovery to Diagnosis

AU - Rayner, Peter J.

AU - Duckett, Simon B.

N1 - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2018/6/4

Y1 - 2018/6/4

N2 - Signal Amplification by Reversible Exchange (SABRE) turns typically weak magnetic resonance responses into strong signals making previously impractical measurements possible. This technique has gained significant popularity due to its speed and simplicity. This minireview tracks the development of SABRE from the initial hyperpolarization of pyridine in 2009, to the point where 50% 1H polarization levels have be achieved in a di-deuterio-nicotinate, a key step in the pathway to potential clinical use. Simple routes to highly efficient 15N hyperpolarization and the creation of hyperpolarized long-lived magnetic states are illustrated. It finishes by describing how the recently reported SABRE-RELAY approach offers a route for parahydrogen to hyperpolarize a much wider array of molecular scaffolds, such as amides, alcohols, carboxylic acids and phosphates, than was previously thought possible. We predict that collectively these developments ensure that SABRE will significantly impact on both chemical analysis and the diagnosis of disease in the future.

AB - Signal Amplification by Reversible Exchange (SABRE) turns typically weak magnetic resonance responses into strong signals making previously impractical measurements possible. This technique has gained significant popularity due to its speed and simplicity. This minireview tracks the development of SABRE from the initial hyperpolarization of pyridine in 2009, to the point where 50% 1H polarization levels have be achieved in a di-deuterio-nicotinate, a key step in the pathway to potential clinical use. Simple routes to highly efficient 15N hyperpolarization and the creation of hyperpolarized long-lived magnetic states are illustrated. It finishes by describing how the recently reported SABRE-RELAY approach offers a route for parahydrogen to hyperpolarize a much wider array of molecular scaffolds, such as amides, alcohols, carboxylic acids and phosphates, than was previously thought possible. We predict that collectively these developments ensure that SABRE will significantly impact on both chemical analysis and the diagnosis of disease in the future.

KW - catalysis

KW - hyperpolarization

KW - MRI

KW - NMR

KW - SABRE

UR - http://www.scopus.com/inward/record.url?scp=85045753260&partnerID=8YFLogxK

U2 - 10.1002/anie.201710406

DO - 10.1002/anie.201710406

M3 - Review article

AN - SCOPUS:85045753260

SN - 1433-7851

VL - 57

SP - 6742

EP - 6753

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 23

ER -