Simple, quick and green isolation of cannabinoids from complex natural product extracts using sustainable mesoporous materials (Starbon®)

Thomas Michael Attard; Christopher Goodwin; Povilas Nalivaika; Jennifer Attard; Vitaliy L Budarin; Alexandra Lanot; Damien Bove; James Hanley Clark; Rob McElroy

doi:10.1039/D2QM00028H

Simple, quick and green isolation of cannabinoids from complex natural product extracts using sustainable mesoporous materials (Starbon®)

Thomas Michael Attard, Christopher Goodwin, Povilas Nalivaika, Jennifer Attard, Vitaliy L Budarin, Alexandra Lanot, Damien Bove, James Hanley Clark, Rob McElroy

Research output: Contribution to journal › Article › peer-review

Abstract

The current process to purify CBD from C. sativa extract is long and intensive, requiring several steps such as winterification for 48 hours at -45 °C and high-temperature, high vacuum distillation. These processes are capital intensive and generate large amounts of toxic solvent waste. In contrast, the solid phase extraction (SPE) methodology proposed herein will change the way CBD is obtained, doing so in a single step that is fast and reusable. Furthermore, the new process is simple and easily implemented and does not require any intensive operator training. Starbon® A300 was successfully employed as the stationary phase in SPE taking Cannabis sativa extract in hexane to selectively physisorb the cannabinoids onto the surface, followed by ethanol to bring about desorption at up to 93% (by GC-FID). A similar one pot system was also proven, using Fedora hemp stem dust as feedstock, with extraction and adsorption in supercritical CO2 followed by desorption in ethanol.

Original language	English
Pages (from-to)	1324-1330
Journal	Materials Chemistry Frontiers
Volume	6
DOIs	https://doi.org/10.1039/D2QM00028H
Publication status	Published - 25 Apr 2022

Bibliographical note

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10.1039/D2QM00028HLicence: CC BY-NC

D2QM00028H
© the Partner Organisations 2022
Accepted author manuscript, 1.34 MBLicence: CC BY-NC

Cite this

@article{e0ce6b5479314b448df93b2aca574d18,

title = "Simple, quick and green isolation of cannabinoids from complex natural product extracts using sustainable mesoporous materials (Starbon{\textregistered})",

abstract = "The current process to purify CBD from C. sativa extract is long and intensive, requiring several steps such as winterification for 48 hours at -45 °C and high-temperature, high vacuum distillation. These processes are capital intensive and generate large amounts of toxic solvent waste. In contrast, the solid phase extraction (SPE) methodology proposed herein will change the way CBD is obtained, doing so in a single step that is fast and reusable. Furthermore, the new process is simple and easily implemented and does not require any intensive operator training. Starbon{\textregistered} A300 was successfully employed as the stationary phase in SPE taking Cannabis sativa extract in hexane to selectively physisorb the cannabinoids onto the surface, followed by ethanol to bring about desorption at up to 93% (by GC-FID). A similar one pot system was also proven, using Fedora hemp stem dust as feedstock, with extraction and adsorption in supercritical CO2 followed by desorption in ethanol.",

author = "Attard, {Thomas Michael} and Christopher Goodwin and Povilas Nalivaika and Jennifer Attard and Budarin, {Vitaliy L} and Alexandra Lanot and Damien Bove and Clark, {James Hanley} and Rob McElroy",

note = " {\textcopyright} the Partner Organisations 2022",

year = "2022",

month = apr,

day = "25",

doi = "10.1039/D2QM00028H",

language = "English",

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journal = "Materials Chemistry Frontiers",

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T1 - Simple, quick and green isolation of cannabinoids from complex natural product extracts using sustainable mesoporous materials (Starbon®)

AU - Attard, Thomas Michael

AU - Goodwin, Christopher

AU - Nalivaika, Povilas

AU - Attard, Jennifer

AU - Budarin, Vitaliy L

AU - Lanot, Alexandra

AU - Bove, Damien

AU - Clark, James Hanley

AU - McElroy, Rob

PY - 2022/4/25

Y1 - 2022/4/25

N2 - The current process to purify CBD from C. sativa extract is long and intensive, requiring several steps such as winterification for 48 hours at -45 °C and high-temperature, high vacuum distillation. These processes are capital intensive and generate large amounts of toxic solvent waste. In contrast, the solid phase extraction (SPE) methodology proposed herein will change the way CBD is obtained, doing so in a single step that is fast and reusable. Furthermore, the new process is simple and easily implemented and does not require any intensive operator training. Starbon® A300 was successfully employed as the stationary phase in SPE taking Cannabis sativa extract in hexane to selectively physisorb the cannabinoids onto the surface, followed by ethanol to bring about desorption at up to 93% (by GC-FID). A similar one pot system was also proven, using Fedora hemp stem dust as feedstock, with extraction and adsorption in supercritical CO2 followed by desorption in ethanol.

AB - The current process to purify CBD from C. sativa extract is long and intensive, requiring several steps such as winterification for 48 hours at -45 °C and high-temperature, high vacuum distillation. These processes are capital intensive and generate large amounts of toxic solvent waste. In contrast, the solid phase extraction (SPE) methodology proposed herein will change the way CBD is obtained, doing so in a single step that is fast and reusable. Furthermore, the new process is simple and easily implemented and does not require any intensive operator training. Starbon® A300 was successfully employed as the stationary phase in SPE taking Cannabis sativa extract in hexane to selectively physisorb the cannabinoids onto the surface, followed by ethanol to bring about desorption at up to 93% (by GC-FID). A similar one pot system was also proven, using Fedora hemp stem dust as feedstock, with extraction and adsorption in supercritical CO2 followed by desorption in ethanol.

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JO - Materials Chemistry Frontiers

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