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Single stranded RNA binding proteins

Research output: Contribution to journalLiterature review

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Publication details

JournalCURRENT OPINION IN STRUCTURAL BIOLOGY
DatePublished - Feb 2000
Issue number1
Volume10
Number of pages8
Pages (from-to)87-94
Original languageEnglish

Abstract

Our knowledge of protein interactions with RNA molecules has been, so far, largely restricted to cases in which the RNA itself is folded into a secondary and/or tertiary structure stabilised by intramolecular base pairing and stacking. Until recently, only limited structural information has been available about protein interactions with single-stranded RNA. A breakthrough in our understanding of these interactions came in 1999, with the determination of four crystal structures of protein complexes with extended single-stranded RNA molecules. These structures revealed wonderfully satisfying patterns of the ability of proteins to accommodate RNA bases, with the sugar-phosphate backbone often adopting conformations that are different from the classical double helix.

    Research areas

  • TERMINATION FACTOR-RHO, SUBTILIS TRP OPERON, BACILLUS-SUBTILIS, CRYSTAL-STRUCTURE, ATTENUATION PROTEIN, ANTICODON RECOGNITION, ANGSTROM RESOLUTION, SPLICE SITE, LEADER RNA, SYNTHETASE

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