Site-selective incorporation and ligation of protein aldehydes

Richard James Spears; Martin Anthony Fascione

doi:10.1039/C6OB00778C

Site-selective incorporation and ligation of protein aldehydes

Richard James Spears, Martin Anthony Fascione

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.

Original language	English
Pages (from-to)	7622-7638
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	32
DOIs	https://doi.org/10.1039/C6OB00778C
Publication status	Published - 30 Jun 2016

Bibliographical note

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10.1039/C6OB00778CLicence: CC BY-NC

c6ob00778c
© The Royal Society of Chemistry 2016
Final published version, 3.9 MBLicence: CC BY-NC

Cite this

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AU - Fascione, Martin Anthony

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AB - The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.

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DO - 10.1039/C6OB00778C

M3 - Review article

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JO - Organic and Biomolecular Chemistry

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