Site-selective incorporation and ligation of protein aldehydes

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Full text download(s)

c6ob00778c
3.9 MB, PDF document

Published copy (DOI)

10.1039/C6OB00778C

Author(s)

Department/unit(s)

Chemistry

Publication details

Journal	Organic and Biomolecular Chemistry
Date	Accepted/In press - 30 Jun 2016
Date	Published (current) - 30 Jun 2016
Issue number	32
Volume	14
Pages (from-to)	7622-7638
Original language	English

Abstract

The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.

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