Site-selective incorporation and ligation of protein aldehydes
Research output: Contribution to journal › Review article › peer-review
Journal | Organic and Biomolecular Chemistry |
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Date | Accepted/In press - 30 Jun 2016 |
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Date | Published (current) - 30 Jun 2016 |
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Issue number | 32 |
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Volume | 14 |
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Pages (from-to) | 7622-7638 |
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Original language | English |
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The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.
© The Royal Society of Chemistry 2016
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