Situating the default-mode network along a principal gradient of macroscale cortical organization

Daniel S Margulies; Satrajit S Ghosh; Alexandros Goulas; Marcel Falkiewicz; Julia M Huntenburg; Georg Langs; Gleb Bezgin; Simon B Eickhoff; F Xavier Castellanos; Michael Petrides; Elizabeth Jefferies; Jonathan Smallwood

doi:10.1073/pnas.1608282113

Situating the default-mode network along a principal gradient of macroscale cortical organization

Daniel S Margulies, Satrajit S Ghosh, Alexandros Goulas, Marcel Falkiewicz, Julia M Huntenburg, Georg Langs, Gleb Bezgin, Simon B Eickhoff, F Xavier Castellanos, Michael Petrides, Elizabeth Jefferies, Jonathan Smallwood

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface-and are precisely equidistant-from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.

Original language	English
Pages (from-to)	12574-12579
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	44
Early online date	18 Oct 2016
DOIs	https://doi.org/10.1073/pnas.1608282113
Publication status	Published - 1 Nov 2016

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© 2016 National Academy of Sciences. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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Margulies, D. S., Ghosh, S. S., Goulas, A., Falkiewicz, M., Huntenburg, J. M., Langs, G., Bezgin, G., Eickhoff, S. B., Castellanos, F. X., Petrides, M., Jefferies, E., & Smallwood, J. (2016). Situating the default-mode network along a principal gradient of macroscale cortical organization. Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12574-12579. https://doi.org/10.1073/pnas.1608282113

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Margulies, DS, Ghosh, SS, Goulas, A, Falkiewicz, M, Huntenburg, JM, Langs, G, Bezgin, G, Eickhoff, SB, Castellanos, FX, Petrides, M, Jefferies, E & Smallwood, J 2016, 'Situating the default-mode network along a principal gradient of macroscale cortical organization', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 44, pp. 12574-12579. https://doi.org/10.1073/pnas.1608282113

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Situating the default-mode network along a principal gradient of macroscale cortical organization

Abstract

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