Sodium homeostasis in the tumour microenvironment

TY - JOUR

T1 - Sodium homeostasis in the tumour microenvironment

AU - Leslie, Theresa Katharina

AU - James, Andrew David

AU - Zaccagna, Fulvio

AU - Grist, James T.

AU - Deen, Surrin

AU - Kennerley, Aneurin James

AU - Riemer, Frank

AU - Kaggie, Joshua D.

AU - Gallagher, Ferdia A.

AU - Gilbert, Fiona J.

AU - Brackenbury, William John

N1 - © 2019 Elsevier B.V. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

PY - 2019/7/23

Y1 - 2019/7/23

N2 - The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requires a large proportion of the cell’s ATP. Na+ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell volume and metabolism as well as immune function. Here, we review evidence indicating that Na+ handling is altered in tumours, explore our current understanding of the mechanisms that may underlie these alterations and consider the potential consequences for cancer progression. Dysregulated Na+ balance in tumours may open opportunities for new imaging biomarkers and re-purposing of drugs for treatment.

AB - The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requires a large proportion of the cell’s ATP. Na+ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell volume and metabolism as well as immune function. Here, we review evidence indicating that Na+ handling is altered in tumours, explore our current understanding of the mechanisms that may underlie these alterations and consider the potential consequences for cancer progression. Dysregulated Na+ balance in tumours may open opportunities for new imaging biomarkers and re-purposing of drugs for treatment.

U2 - 10.1016/j.bbcan.2019.07.001

DO - 10.1016/j.bbcan.2019.07.001

M3 - Article

VL - 1872

SP - 1

EP - 16

JO - BBA - Reviews on Cancer

JF - BBA - Reviews on Cancer

IS - 2

ER -