Solid phase synthesis of functionalised SAM- forming alkanethiol–oligoethyleneglycols

James Murray; Dominika Nowak; Laurynas Pukenas; Rizuan Azhar; Mathieu Guilorit; Christoph Walti; Kevin Critchley; Steven David Johnson; Robin Bon

doi:10.1039/c4tb00573b

Solid phase synthesis of functionalised SAM- forming alkanethiol–oligoethyleneglycols

James Murray, Dominika Nowak, Laurynas Pukenas, Rizuan Azhar, Mathieu Guilorit, Christoph Walti, Kevin Critchley, Steven David Johnson, Robin Bon

Electronic Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alka- nethiol–oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT–OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT–OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.

Original language	English
Pages (from-to)	3741-3744
Number of pages	4
Journal	Journal of Materials Chemistry B
Volume	2
Issue number	24
Early online date	23 Apr 2014
DOIs	https://doi.org/10.1039/c4tb00573b
Publication status	Published - 2014

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10.1039/c4tb00573b

C2D2 research 1b - Point-of-care, electronic detection of pathogenic bacteria using redox-active biomarkers
Johnson, S. D. (Principal investigator) & Moir, J. (Co-investigator)
1/07/12 → 31/03/13
Project: Other project › Other internal award

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title = "Solid phase synthesis of functionalised SAM- forming alkanethiol–oligoethyleneglycols",

abstract = "We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alka- nethiol–oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT–OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT–OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.",

author = "James Murray and Dominika Nowak and Laurynas Pukenas and Rizuan Azhar and Mathieu Guilorit and Christoph Walti and Kevin Critchley and Johnson, {Steven David} and Robin Bon",

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doi = "10.1039/c4tb00573b",

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volume = "2",

pages = "3741--3744",

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publisher = "The Royal Society of Chemistry",

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T1 - Solid phase synthesis of functionalised SAM- forming alkanethiol–oligoethyleneglycols

AU - Murray, James

AU - Nowak, Dominika

AU - Pukenas, Laurynas

AU - Azhar, Rizuan

AU - Guilorit, Mathieu

AU - Walti, Christoph

AU - Critchley, Kevin

AU - Johnson, Steven David

AU - Bon, Robin

PY - 2014

Y1 - 2014

N2 - We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alka- nethiol–oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT–OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT–OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.

AB - We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alka- nethiol–oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT–OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT–OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.

U2 - 10.1039/c4tb00573b

DO - 10.1039/c4tb00573b

M3 - Article

SN - 2050-7518

VL - 2

SP - 3741

EP - 3744

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 24

ER -

Solid phase synthesis of functionalised SAM- forming alkanethiol–oligoethyleneglycols

Abstract

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Projects

C2D2 research 1b - Point-of-care, electronic detection of pathogenic bacteria using redox-active biomarkers

Cite this