Solvent effects in palladium catalysed cross-coupling reactions

James Richard Sherwood; James Hanley Clark; Ian James Stewart Fairlamb; John Martin Slattery

doi:10.1039/C9GC00617F

Solvent effects in palladium catalysed cross-coupling reactions

James Richard Sherwood, James Hanley Clark, Ian James Stewart Fairlamb, John Martin Slattery

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Palladium catalysed cross-couplings reactions have been a dominant method in synthetic chemistry for decades. Despite this, the role of the solvent is often taken for granted and poorly understood. Regulations affecting some the most frequently used solvents for cross-coupling reactions are accelerating current trends towards using new types of solvents. In this review, the fundamental interactions between solvent and catalyst are explained so that it may inform the rational selection of high performance and safe solvents. The popular cross-coupling methodologies are addressed (Suzuki, Stille, Kumada, Negishi, Hiyama, Heck, Sonogashira, and Buchwald–Hartwig reactions) and novel solvents introduced.

Original language	English
Pages (from-to)	2164-2213
Number of pages	50
Journal	Green Chemistry
Early online date	8 Apr 2019
DOIs	https://doi.org/10.1039/C9GC00617F
Publication status	E-pub ahead of print - 8 Apr 2019

Bibliographical note

© The Royal Society of Chemistry 2019. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Keywords

palladium
catalysis
solvents
CROSS-COUPLING REACTION
MECHANISM

Access to Document

10.1039/C9GC00617F

Solvents for x-coupling (accepted manuscript)
© The Royal Society of Chemistry 2019. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
Accepted author manuscript, 3.47 MBLicence: Unspecified

Cite this

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