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Solvent effects in palladium catalysed cross-coupling reactions

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Publication details

JournalGreen Chemistry
DateAccepted/In press - 3 Apr 2019
DateE-pub ahead of print (current) - 8 Apr 2019
Number of pages50
Pages (from-to)2164-2213
Early online date8/04/19
Original languageEnglish


Palladium catalysed cross-couplings reactions have been a dominant method in synthetic chemistry for decades. Despite this, the role of the solvent is often taken for granted and poorly understood. Regulations affecting some the most frequently used solvents for cross-coupling reactions are accelerating current trends towards using new types of solvents. In this review, the fundamental interactions between solvent and catalyst are explained so that it may inform the rational selection of high performance and safe solvents. The popular cross-coupling methodologies are addressed (Suzuki, Stille, Kumada, Negishi, Hiyama, Heck, Sonogashira, and Buchwald–Hartwig reactions) and novel solvents introduced.

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© The Royal Society of Chemistry 2019. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

    Research areas

  • palladium, catalysis, solvents, CROSS-COUPLING REACTION, MECHANISM

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