Spatial learning and hippocampal long-term potentiation are not impaired in mdx mice

A K Sesay; M L Errington; L Levita; T V Bliss

Spatial learning and hippocampal long-term potentiation are not impaired in mdx mice

A K Sesay, M L Errington, L Levita, T V Bliss

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Moderate non-progressive cognitive impairment is a consistent feature of Duchenne muscular dystrophy (DMD), although few central nervous system abnormalities have yet been identified. A model for DMD is provided by the mdx mouse which fails to produce full length dystrophin in muscle and brain. In this study we have compared performances in a hippocampal-dependent spatial learning task, the Morris water maze, in mdx mice and in age-matched normal (C57BL/10) mice. There was no difference in acquisition rates or in retention between the two groups. We also found no difference in the magnitude of long-term potentiation (LTP) between the two groups, either in the dentate gyrus or in area CA. These experiments demonstrate that neither spatial learning nor hippocampal synaptic plasticity are significantly affected by the lack of full-length dystrophin.

Original language	English
Pages (from-to)	207-10
Number of pages	4
Journal	NEUROSCIENCE LETTERS
Volume	211
Issue number	3
Publication status	Published - 1996

Keywords

Animals
Hippocampus
Learning
Long-Term Potentiation
Mice
Mice, Inbred mdx

Cite this

@article{39275d5a4ca54655bf6fbd4ba75abfb0,

title = "Spatial learning and hippocampal long-term potentiation are not impaired in mdx mice",

abstract = "Moderate non-progressive cognitive impairment is a consistent feature of Duchenne muscular dystrophy (DMD), although few central nervous system abnormalities have yet been identified. A model for DMD is provided by the mdx mouse which fails to produce full length dystrophin in muscle and brain. In this study we have compared performances in a hippocampal-dependent spatial learning task, the Morris water maze, in mdx mice and in age-matched normal (C57BL/10) mice. There was no difference in acquisition rates or in retention between the two groups. We also found no difference in the magnitude of long-term potentiation (LTP) between the two groups, either in the dentate gyrus or in area CA. These experiments demonstrate that neither spatial learning nor hippocampal synaptic plasticity are significantly affected by the lack of full-length dystrophin.",

keywords = "Animals, Hippocampus, Learning, Long-Term Potentiation, Mice, Mice, Inbred mdx",

author = "Sesay, {A K} and Errington, {M L} and L Levita and Bliss, {T V}",

year = "1996",

language = "English",

volume = "211",

pages = "207--10",

journal = "NEUROSCIENCE LETTERS",

issn = "0304-3940",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Spatial learning and hippocampal long-term potentiation are not impaired in mdx mice

AU - Sesay, A K

AU - Errington, M L

AU - Levita, L

AU - Bliss, T V

PY - 1996

Y1 - 1996

N2 - Moderate non-progressive cognitive impairment is a consistent feature of Duchenne muscular dystrophy (DMD), although few central nervous system abnormalities have yet been identified. A model for DMD is provided by the mdx mouse which fails to produce full length dystrophin in muscle and brain. In this study we have compared performances in a hippocampal-dependent spatial learning task, the Morris water maze, in mdx mice and in age-matched normal (C57BL/10) mice. There was no difference in acquisition rates or in retention between the two groups. We also found no difference in the magnitude of long-term potentiation (LTP) between the two groups, either in the dentate gyrus or in area CA. These experiments demonstrate that neither spatial learning nor hippocampal synaptic plasticity are significantly affected by the lack of full-length dystrophin.

AB - Moderate non-progressive cognitive impairment is a consistent feature of Duchenne muscular dystrophy (DMD), although few central nervous system abnormalities have yet been identified. A model for DMD is provided by the mdx mouse which fails to produce full length dystrophin in muscle and brain. In this study we have compared performances in a hippocampal-dependent spatial learning task, the Morris water maze, in mdx mice and in age-matched normal (C57BL/10) mice. There was no difference in acquisition rates or in retention between the two groups. We also found no difference in the magnitude of long-term potentiation (LTP) between the two groups, either in the dentate gyrus or in area CA. These experiments demonstrate that neither spatial learning nor hippocampal synaptic plasticity are significantly affected by the lack of full-length dystrophin.

KW - Animals

KW - Hippocampus

KW - Learning

KW - Long-Term Potentiation

KW - Mice

KW - Mice, Inbred mdx

M3 - Article

C2 - 8817577

SN - 0304-3940

VL - 211

SP - 207

EP - 210

JO - NEUROSCIENCE LETTERS

JF - NEUROSCIENCE LETTERS

IS - 3

ER -