Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity

Gerardo Zavala; Kurt Z. Long; Olga P. García; María Del Carmen Caamaño; Tania Aguilar; Luis M. Salgado; Jorge L. Rosado

doi:10.1017/S0007114512001912

Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity

Gerardo Zavala, Kurt Z. Long, Olga P. García, María Del Carmen Caamaño, Tania Aguilar, Luis M. Salgado, Jorge L. Rosado^*

^*Corresponding author for this work

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the concentrations of inflammatory cytokines. A cross-sectional study was carried out to evaluate the association of specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (sd 7·5) years) from seven rural communities in Mexico. Measurements of weight, height and waist circumference were made on all women and body composition was determined by dual-energy X-ray absorptiometry. Concentrations of the cytokines IL-1, TNF-α, IL-6, IL-10 and IL-12, lipid profile, and the micronutrients Zn and vitamins A, C and E were determined in fasting blood samples. Ordered logistic regression models were used to determine associations between categorised cytokine levels and micronutrients. It was found that 80Â % of women were overweight or obese, and had significantly higher concentrations of C-reactive protein than normal-weight women (P=Â 0·05). The risk of higher levels of TNF-α, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0·63, 95Â % CI 0·42, 0·96, P=Â 0·03; OR 0·57, 95Â % CI 0·39, 0·86, P=Â 0·025; OR 0·63, 95Â % CI 0·41, 0·96, P=Â 0·04; OR 0·62, 95Â % CI 0·41, 0·95, P=Â 0·03, respectively). Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0·97, 95Â % CI 0·95, 0·99, P=Â 0·03; OR 0·97, 95Â % CI 0·94, 0·99, P=Â 0·03, respectively); when adjusting for BMI, this association was lost. No associations were found between vitamin C or vitamin E:lipids concentrations and inflammatory cytokines. In conclusion, higher Zn concentrations are associated with reduced risks of higher concentration of inflammation markers in a population of women with a high prevalence of obesity.

Original language	English
Pages (from-to)	686-694
Number of pages	9
Journal	BRITISH JOURNAL OF NUTRITION
Volume	109
Issue number	4
DOIs	https://doi.org/10.1017/S0007114512001912
Publication status	Published - 28 Feb 2013

Keywords

Cytokines
Micronutrients: Obesity

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10.1017/S0007114512001912

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@article{15a502558f18491eb2c0e8f25959ae10,

title = "Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity",

abstract = "It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the concentrations of inflammatory cytokines. A cross-sectional study was carried out to evaluate the association of specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (sd 7·5) years) from seven rural communities in Mexico. Measurements of weight, height and waist circumference were made on all women and body composition was determined by dual-energy X-ray absorptiometry. Concentrations of the cytokines IL-1, TNF-α, IL-6, IL-10 and IL-12, lipid profile, and the micronutrients Zn and vitamins A, C and E were determined in fasting blood samples. Ordered logistic regression models were used to determine associations between categorised cytokine levels and micronutrients. It was found that 80{\^A} % of women were overweight or obese, and had significantly higher concentrations of C-reactive protein than normal-weight women (P={\^A} 0·05). The risk of higher levels of TNF-α, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0·63, 95{\^A} % CI 0·42, 0·96, P={\^A} 0·03; OR 0·57, 95{\^A} % CI 0·39, 0·86, P={\^A} 0·025; OR 0·63, 95{\^A} % CI 0·41, 0·96, P={\^A} 0·04; OR 0·62, 95{\^A} % CI 0·41, 0·95, P={\^A} 0·03, respectively). Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0·97, 95{\^A} % CI 0·95, 0·99, P={\^A} 0·03; OR 0·97, 95{\^A} % CI 0·94, 0·99, P={\^A} 0·03, respectively); when adjusting for BMI, this association was lost. No associations were found between vitamin C or vitamin E:lipids concentrations and inflammatory cytokines. In conclusion, higher Zn concentrations are associated with reduced risks of higher concentration of inflammation markers in a population of women with a high prevalence of obesity.",

keywords = "Cytokines, Micronutrients: Obesity",

author = "Gerardo Zavala and Long, {Kurt Z.} and Garc{\'i}a, {Olga P.} and Caama{\~n}o, {Mar{\'i}a Del Carmen} and Tania Aguilar and Salgado, {Luis M.} and Rosado, {Jorge L.}",

year = "2013",

month = feb,

day = "28",

doi = "10.1017/S0007114512001912",

language = "English",

volume = "109",

pages = "686--694",

journal = "BRITISH JOURNAL OF NUTRITION",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "4",

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TY - JOUR

T1 - Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity

AU - Zavala, Gerardo

AU - Long, Kurt Z.

AU - García, Olga P.

AU - Caamaño, María Del Carmen

AU - Aguilar, Tania

AU - Salgado, Luis M.

AU - Rosado, Jorge L.

PY - 2013/2/28

Y1 - 2013/2/28

N2 - It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the concentrations of inflammatory cytokines. A cross-sectional study was carried out to evaluate the association of specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (sd 7·5) years) from seven rural communities in Mexico. Measurements of weight, height and waist circumference were made on all women and body composition was determined by dual-energy X-ray absorptiometry. Concentrations of the cytokines IL-1, TNF-α, IL-6, IL-10 and IL-12, lipid profile, and the micronutrients Zn and vitamins A, C and E were determined in fasting blood samples. Ordered logistic regression models were used to determine associations between categorised cytokine levels and micronutrients. It was found that 80Â % of women were overweight or obese, and had significantly higher concentrations of C-reactive protein than normal-weight women (P=Â 0·05). The risk of higher levels of TNF-α, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0·63, 95Â % CI 0·42, 0·96, P=Â 0·03; OR 0·57, 95Â % CI 0·39, 0·86, P=Â 0·025; OR 0·63, 95Â % CI 0·41, 0·96, P=Â 0·04; OR 0·62, 95Â % CI 0·41, 0·95, P=Â 0·03, respectively). Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0·97, 95Â % CI 0·95, 0·99, P=Â 0·03; OR 0·97, 95Â % CI 0·94, 0·99, P=Â 0·03, respectively); when adjusting for BMI, this association was lost. No associations were found between vitamin C or vitamin E:lipids concentrations and inflammatory cytokines. In conclusion, higher Zn concentrations are associated with reduced risks of higher concentration of inflammation markers in a population of women with a high prevalence of obesity.

AB - It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the concentrations of inflammatory cytokines. A cross-sectional study was carried out to evaluate the association of specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (sd 7·5) years) from seven rural communities in Mexico. Measurements of weight, height and waist circumference were made on all women and body composition was determined by dual-energy X-ray absorptiometry. Concentrations of the cytokines IL-1, TNF-α, IL-6, IL-10 and IL-12, lipid profile, and the micronutrients Zn and vitamins A, C and E were determined in fasting blood samples. Ordered logistic regression models were used to determine associations between categorised cytokine levels and micronutrients. It was found that 80Â % of women were overweight or obese, and had significantly higher concentrations of C-reactive protein than normal-weight women (P=Â 0·05). The risk of higher levels of TNF-α, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0·63, 95Â % CI 0·42, 0·96, P=Â 0·03; OR 0·57, 95Â % CI 0·39, 0·86, P=Â 0·025; OR 0·63, 95Â % CI 0·41, 0·96, P=Â 0·04; OR 0·62, 95Â % CI 0·41, 0·95, P=Â 0·03, respectively). Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0·97, 95Â % CI 0·95, 0·99, P=Â 0·03; OR 0·97, 95Â % CI 0·94, 0·99, P=Â 0·03, respectively); when adjusting for BMI, this association was lost. No associations were found between vitamin C or vitamin E:lipids concentrations and inflammatory cytokines. In conclusion, higher Zn concentrations are associated with reduced risks of higher concentration of inflammation markers in a population of women with a high prevalence of obesity.

KW - Cytokines

KW - Micronutrients: Obesity

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U2 - 10.1017/S0007114512001912

DO - 10.1017/S0007114512001912

M3 - Article

C2 - 22640991

AN - SCOPUS:84885822734

SN - 0007-1145

VL - 109

SP - 686

EP - 694

JO - BRITISH JOURNAL OF NUTRITION

JF - BRITISH JOURNAL OF NUTRITION

IS - 4

ER -

Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity

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Keywords

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