Abstract
Both free-radical and non-radical routes for peroxide oxidation of Cu-I can be identified for copper complexes obtained by the reduction of Cu-II by thiols, including glutathione. Copper(I)-thiolate complexes are obtained, except in the presence of e.g. 1,10-phenanthroline, and these undergo ready reaction with H2O2 and (BuOOH)-Bu-t. EPR spin-trapping studies establish a free-radical reaction mechanism (to give (BuO.)-Bu-t) with the latter, and the formation of HO. from the former occurs only at low concentrations of copper. Kinetic studies (using UV-vis and EPR spectroscopies), together with NMR analysis, lead to the proposal that Cu-I aggregates react via non-radical pathways in contrast to monomeric Cu-I.
Original language | English |
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Pages (from-to) | 1115-1121 |
Number of pages | 7 |
Journal | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 |
Issue number | 6 |
Publication status | Published - Jun 1999 |
Keywords
- HYDROGEN-PEROXIDE
- DNA-DAMAGE
- COPPER
- ION
- CLEAVAGE
- H2O2