Stereoselective radical reactions

G  Bar; A F  Parsons

doi:10.1039/b111414j

Stereoselective radical reactions

G Bar, A F Parsons

Chemistry

Research output: Contribution to journal › Literature review › peer-review

Abstract

For many years, the reputed lack of selectivity in some free-radical reactions has resulted in this class of reaction being overlooked in the stereoselective synthesis of important target molecules. More recently, however, the situation has changed as new and milder methods of radical generation have been developed, which have helped researchers to gain a better understanding of the key factors that influence selectivity in radical transformations. As a consequence, the use of radicals in stereoselective synthesis is increasing and there are a number of important intra- and intermolecular additions, where high levels of stereoselectivity have been achieved in the formation of carbon-carbon bonds.

Original language	English
Pages (from-to)	251-263
Number of pages	13
Journal	Chemical Society Reviews
Volume	32
Issue number	5
DOIs	https://doi.org/10.1039/b111414j
Publication status	Published - Sept 2003

Keywords

ATOM-TRANSFER
CYCLIZATION REACTIONS
ENANTIOSELECTIVE SYNTHESIS
MEDIATED ALLYLATION
CONJUGATE ADDITIONS
CHIRAL AUXILIARIES
ACID
TANDEM
SELECTIVITY
DERIVATIVES

Access to Document

10.1039/b111414j

Cite this

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title = "Stereoselective radical reactions",

abstract = "For many years, the reputed lack of selectivity in some free-radical reactions has resulted in this class of reaction being overlooked in the stereoselective synthesis of important target molecules. More recently, however, the situation has changed as new and milder methods of radical generation have been developed, which have helped researchers to gain a better understanding of the key factors that influence selectivity in radical transformations. As a consequence, the use of radicals in stereoselective synthesis is increasing and there are a number of important intra- and intermolecular additions, where high levels of stereoselectivity have been achieved in the formation of carbon-carbon bonds.",

keywords = "ATOM-TRANSFER, CYCLIZATION REACTIONS, ENANTIOSELECTIVE SYNTHESIS, MEDIATED ALLYLATION, CONJUGATE ADDITIONS, CHIRAL AUXILIARIES, ACID, TANDEM, SELECTIVITY, DERIVATIVES",

author = "G Bar and Parsons, {A F}",

year = "2003",

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language = "English",

volume = "32",

pages = "251--263",

journal = "Chemical Society Reviews",

publisher = "The Royal Society of Chemistry",

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T1 - Stereoselective radical reactions

AU - Bar, G

AU - Parsons, A F

PY - 2003/9

Y1 - 2003/9

N2 - For many years, the reputed lack of selectivity in some free-radical reactions has resulted in this class of reaction being overlooked in the stereoselective synthesis of important target molecules. More recently, however, the situation has changed as new and milder methods of radical generation have been developed, which have helped researchers to gain a better understanding of the key factors that influence selectivity in radical transformations. As a consequence, the use of radicals in stereoselective synthesis is increasing and there are a number of important intra- and intermolecular additions, where high levels of stereoselectivity have been achieved in the formation of carbon-carbon bonds.

AB - For many years, the reputed lack of selectivity in some free-radical reactions has resulted in this class of reaction being overlooked in the stereoselective synthesis of important target molecules. More recently, however, the situation has changed as new and milder methods of radical generation have been developed, which have helped researchers to gain a better understanding of the key factors that influence selectivity in radical transformations. As a consequence, the use of radicals in stereoselective synthesis is increasing and there are a number of important intra- and intermolecular additions, where high levels of stereoselectivity have been achieved in the formation of carbon-carbon bonds.

KW - ATOM-TRANSFER

KW - CYCLIZATION REACTIONS

KW - ENANTIOSELECTIVE SYNTHESIS

KW - MEDIATED ALLYLATION

KW - CONJUGATE ADDITIONS

KW - CHIRAL AUXILIARIES

KW - ACID

KW - TANDEM

KW - SELECTIVITY

KW - DERIVATIVES

U2 - 10.1039/b111414j

DO - 10.1039/b111414j

M3 - Literature review

VL - 32

SP - 251

EP - 263

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 5

ER -