Stereoselective synthesis of an advanced trans-decalin intermediate towards the total synthesis of anthracimycin

Laksamee Jeanmard, Giacomo Lodovici, Ian George, Joshua T W Bray, Adrian C Whitwood, Gavin H Thomas, Ian J S Fairlamb, William P Unsworth, Paul A Clarke

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Progress towards the total synthesis of the macrolide natural product anthracimycin is described. This new approach utilises an intermolecular Diels-Alder strategy followed by epimeirsation to form the key trans-decalin framework. The route culminates in the stereoselective synthesis of an advanced tricyclic lactone intermediate, containing five contiguous sterogenic centres with the correct relative and absolute stereochemistry required for the anthracimycin core motif.

Original languageEnglish
Number of pages4
JournalChemical communications
Early online date7 May 2024
Publication statusE-pub ahead of print - 7 May 2024

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© The Royal Society of Chemistry 2024

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