Steric and Electronic Effects on the 1H Hyperpolarisation of Substituted Pyridazines by Signal Amplification by Reversible Exchange

Research output: Contribution to journalArticlepeer-review


Utility of the pyridazine motif is growing in popularity as pharmaceutical and agrochemical agents. The detection and structural characterisation of such materials is therefore imperative for the successful development of new products. Signal Amplification by Reversible Exchange (SABRE) offers a route to dramatically improve the sensitivity of magnetic resonance methods and we apply it here to the rapid and cost effective hyperpolarisation of substituted pyridazines. The 33 substrates investigated cover a range of steric and electronic properties and their capacity to perform highly effective SABRE to be assessed. We find the method to be tolerant to a broad range of electron donating and withdrawing groups, however, sensitivity is evident when steric bulk is added to the 3 and 6-positions of the pyridazine ring. We optimise the method by reference to a disubstituted ester that yields signal gains of >9 000-fold at 9.4 T (>28% spin polarisation).
Original languageEnglish
Pages (from-to)1187-1198
Issue number12
Early online date17 Mar 2021
Publication statusPublished - 14 Nov 2021

Bibliographical note

© 2021 The Authors

Cite this