Projects per year
Abstract
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years. While methods like cyclisation onto oxocarbenium ions, reduction of cyclic hemi ketals, Michael reactions, hetero-Diels–Alder cycloadditions and cyclisations onto epoxides continue to find application, several other strategies including metal-mediated cyclisations, ring-closing metathesis, radical cyclisations and carbocation cyclisations have also found use. This review is intended to provide an overview of the area for those who are unfamiliar, and to refresh and remind those who do work in the area of the exciting developments in the field.
Original language | English |
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Pages (from-to) | 3323-3335 |
Number of pages | 13 |
Journal | Organic and Biomolecular Chemistry |
Volume | 12 |
Issue number | 21 |
Early online date | 4 Apr 2014 |
DOIs | |
Publication status | Published - 7 Jun 2014 |
Projects
- 2 Finished
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Synthesis of Functionalised Tetrahydropyrans via Modifications of the Maitland-Japp Reaction
Clarke, P. A. (Principal investigator), Mad Nasir, M. (Principal investigator) & Sellars, P. B. (Student)
1/01/13 → 30/06/16
Project: Other project › Research collaboration
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Stereodivergent Synthesis of Tetrahydropyran-Containing Natural Products
Clarke, P. A. (Principal investigator), Ermanis, K. (Student) & Hsiao, Y.-T. (Student)
1/10/10 → 31/03/17
Project: Other project › Research collaboration