Strategies for the Construction of Tetrahydropyran Rings in the Synthesis of Natural Products

Kristaps Ermanis, Nadiah Mad Nasir, Paul A. Clarke

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years. While methods like cyclisation onto oxocarbenium ions, reduction of cyclic hemi ketals, Michael reactions, hetero-Diels–Alder cycloadditions and cyclisations onto epoxides continue to find application, several other strategies including metal-mediated cyclisations, ring-closing metathesis, radical cyclisations and carbocation cyclisations have also found use. This review is intended to provide an overview of the area for those who are unfamiliar, and to refresh and remind those who do work in the area of the exciting developments in the field.
Original languageEnglish
Pages (from-to)3323-3335
Number of pages13
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number21
Early online date4 Apr 2014
DOIs
Publication statusPublished - 7 Jun 2014

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