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Strategies for the Construction of Tetrahydropyran Rings in the Synthesis of Natural Products

Research output: Contribution to journalLiterature review

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Publication details

JournalOrganic and Biomolecular Chemistry
DateE-pub ahead of print - 4 Apr 2014
DatePublished (current) - 7 Jun 2014
Issue number21
Number of pages13
Pages (from-to)3323-3335
Early online date4/04/14
Original languageEnglish


This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years. While methods like cyclisation onto oxocarbenium ions, reduction of cyclic hemi ketals, Michael reactions, hetero-Diels–Alder cycloadditions and cyclisations onto epoxides continue to find application, several other strategies including metal-mediated cyclisations, ring-closing metathesis, radical cyclisations and carbocation cyclisations have also found use. This review is intended to provide an overview of the area for those who are unfamiliar, and to refresh and remind those who do work in the area of the exciting developments in the field.

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