Abstract
Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-β-galactosaminidase that acts with retention of stereochemistry, and, through a 3-D structure in complex with Gal-thiazoline, provide evidence in support of a neighbouring group participation mechanism.
Original language | English |
---|---|
Pages (from-to) | 11096-11099 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 52 |
Issue number | 74 |
Early online date | 15 Aug 2016 |
DOIs | |
Publication status | Published - 25 Sept 2016 |