Structural and sequence-based classification of glycoside hydrolases

B Henrissat, G Davies

Research output: Contribution to journalArticlepeer-review

Abstract

The diversity of oligo-and polysaccharides provides an abundance of biological roles for these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases, therefore mediate a wealth of biological functions. Glycoside hydrolases fall into a number of sequence-based families. The recent analysis of these families, coupled with the burgeoning number of 3D structures, provides a detailed insight into the structure, function and catalytic mechanism of these enzymes.The diversity of oligo-and polysaccharides provides an abundance of biological roles for these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases, therefore mediate a wealth of biological functions. Glycoside hydrolases fall into a number of sequence-based families. The recent analysis of these families, coupled with the burgeoning number of 3D structures, provides a detailed insight into the structure, function and catalytic mechanism of these enzymes. (C) Current Biology Ltd ISSN 0959-440X

Original languageEnglish
Pages (from-to)637-644
Number of pages8
JournalCURRENT OPINION IN STRUCTURAL BIOLOGY
Volume7
Issue number5
Publication statusPublished - Oct 1997

Keywords

  • REFINED CRYSTAL-STRUCTURE
  • 1.8 ANGSTROM RESOLUTION
  • ACTIVE-SITE
  • TRICHODERMA-REESEI
  • 3-DIMENSIONAL STRUCTURE
  • CATALYTIC MECHANISM
  • BETA-GALACTOSIDASE
  • CELLULOMONAS-FIMI
  • ENDOGLUCANASE
  • COMPLEX

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