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Structural basis of malodour precursor transport in the human axilla

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JournaleLife
DateAccepted/In press - 16 Jun 2018
DatePublished (current) - 3 Jul 2018
Volume7
Number of pages26
Original languageEnglish

Abstract

Mammals produce volatile odours that convey different types of societal information. In Homo sapiens, this is now recognised as body odour, a key chemical component of which is the sulphurous thioalcohol, 3-methyl-3-sulfanylhexan-1-ol (3M3SH). Volatile 3M3SH is produced in the underarm as a result of specific microbial activity, which act on the odourless dipeptide-containing malodour precursor molecule, S-Cys-Gly-3M3SH, secreted in the axilla (underarm) during colonisation. The mechanism by which these bacteria recognise S-Cys-Gly-3M3SH and produce body odour is still poorly understood. Here we report the structural and biochemical basis of bacterial transport of S-Cys-Gly-3M3SH by Staphylococcus hominis, which is converted to the sulphurous thioalcohol component 3M3SH in the bacterial cytoplasm, before being released into the environment. Knowledge of the molecular basis of precursor transport, essential for body odour formation, provides a novel opportunity to design specific inhibitors of malodour production in humans.

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© 2018, Minhas et al.

    Research areas

  • Axilla/microbiology, Bacterial Proteins/chemistry, Binding Sites, Biological Transport, Biotransformation, Carrier Proteins/chemistry, Crystallography, X-Ray, Cytoplasm/metabolism, Dipeptides/chemistry, Gene Expression Regulation, Bacterial, Hexanols/chemistry, Humans, Kinetics, Models, Molecular, Odorants/analysis, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Recombinant Proteins/chemistry, Staphylococcus hominis/genetics, Substrate Specificity, Sulfanilic Acids/chemistry, Sweat/chemistry

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