Projects per year
Abstract
Understanding the fundamental principles of virus architecture is one of the most important challenges in biology and medicine. Crick and Watson were the first to propose that viruses exhibit symmetry in the organization of their protein containers for reasons of genetic economy. Based on this, Caspar and Klug introduced quasi-equivalence theory to predict the relative locations of the coat proteins within these containers and classified virus structure in terms of T-numbers. Here it is shown that quasi-equivalence is part of a wider set of structural constraints on virus structure. These constraints can be formulated using an extension of the underlying symmetry group and this is demonstrated with a number of case studies. This new concept in virus biology provides for the first time predictive information on the structural constraints on coat protein and genome topography, and reveals a previously unrecognized structural interdependence of the shapes and sizes of different viral components. It opens up the possibility of distinguishing the structures of different viruses with the same T-number, suggesting a refined viral structure classification scheme. It can moreover be used as a basis for models of virus function, e.g. to characterize the start and end configurations of a structural transition important for infection.
Original language | English |
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Pages (from-to) | 140-150 |
Number of pages | 11 |
Journal | Acta Crystallographica Section A: Foundations of Crystallography |
Volume | 69 |
Issue number | Pt 2 |
Early online date | 8 Jan 2013 |
DOIs | |
Publication status | Published - Mar 2013 |
Keywords
- Algorithms
- Capsid Proteins
- Crystallography, X-Ray
- Escherichia coli Infections
- Genome, Viral
- Humans
- Predictive Value of Tests
- RNA Viruses
Projects
- 1 Finished
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Mathematical Virology: The Impact of Virus Structure and
14/02/12 → 13/09/12
Project: Research project (funded) › Research