TY - JOUR
T1 - Structural glycobiology in the age of electron cryo-microscopy
AU - Atanasova, Mihaela
AU - Bagdonas, Haroldas
AU - Agirre, Jon
N1 - © 2019 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years. This is a very timely development, as the resolution revolution in electron cryo-microscopy is now routinely delivering structures of key glycomedical importance, with a three-dimensional precision where X-ray crystallographic methods have traditionally floundered. This review will focus on the new software developments that have been introduced in the past two years, and their impact on the field of structural glycobiology in terms of published structures.
AB - The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years. This is a very timely development, as the resolution revolution in electron cryo-microscopy is now routinely delivering structures of key glycomedical importance, with a three-dimensional precision where X-ray crystallographic methods have traditionally floundered. This review will focus on the new software developments that have been introduced in the past two years, and their impact on the field of structural glycobiology in terms of published structures.
UR - http://www.scopus.com/inward/record.url?scp=85076685201&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2019.12.003
DO - 10.1016/j.sbi.2019.12.003
M3 - Review article
AN - SCOPUS:85076685201
SN - 0959-440X
VL - 62
SP - 70
EP - 78
JO - CURRENT OPINION IN STRUCTURAL BIOLOGY
JF - CURRENT OPINION IN STRUCTURAL BIOLOGY
ER -