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Structural glycobiology in the age of electron cryo-microscopy

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JournalCURRENT OPINION IN STRUCTURAL BIOLOGY
DateE-pub ahead of print (current) - 23 Dec 2019
DatePublished - 1 Jun 2020
Volume62
Number of pages9
Pages (from-to)70-78
Early online date23/12/19
Original languageEnglish

Abstract

The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years. This is a very timely development, as the resolution revolution in electron cryo-microscopy is now routinely delivering structures of key glycomedical importance, with a three-dimensional precision where X-ray crystallographic methods have traditionally floundered. This review will focus on the new software developments that have been introduced in the past two years, and their impact on the field of structural glycobiology in terms of published structures.

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© 2019 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

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