Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 (TOC1)

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JournalJournal of circadian rhythms
DatePublished - 25 Feb 2008
Pages (from-to)3
Original languageEnglish


The plant circadian clock has at its core a feedback loop that includes TIMING OF CAB2 EXPRESSION 1 (TOC1). This protein has an as of yet unknown biochemical activity. It has been noted that the extreme amino-terminus of this protein is distantly related in sequence to response regulators (RR), and thus TOC1 is a member of the so-called pseudo response regulator (PRR) family. As well, the extreme carboxy-terminus has a small sequence stretch related to the other PRRs and CONSTANS (CO)-like proteins, and this peptide stretch has been termed the CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain.

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