Activities per year
Inhibitors of Leishmania N-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained, and the active diastereoisomer of one of the inhibitors was identified. On the basis of structural insights, enzyme inhibition was increased 40-fold through hybridization of two distinct binding modes, resulting in novel, highly potent Leishmania donovani NMT inhibitors with good selectivity over the human enzyme.
Anthony J Wilkinson (Invited speaker)12 Mar 2019
Activity: Talk or presentation › Invited talk
Anthony J Wilkinson (Invited speaker)11 Mar 2019 → 15 Mar 2019
Activity: Participating in or organising an event › Conference participation