Structure-Guided Design of C3-Branched Swainsonine as Potent and Selective Human Golgi α-Mannosidase (GMII) Inhibitor

Tony Koemans; Megan Bennett; Maria J. Ferraz; Zachary Armstrong; Marta Artola; Johannes M. F. G. Aerts; Jeroen D. C. Codée; Herman S. Overkleeft; Gideon J. Davies

doi:10.1039/d4cc04514a

Structure-Guided Design of C3-Branched Swainsonine as Potent and Selective Human Golgi α-Mannosidase (GMII) Inhibitor

Tony Koemans, Megan Bennett, Maria J. Ferraz, Zachary Armstrong, Marta Artola, Johannes M. F. G. Aerts, Jeroen D. C. Codée, Herman S. Overkleeft, Gideon J. Davies

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Chemical Communications
Early online date	20 Sept 2024
DOIs	https://doi.org/10.1039/d4cc04514a
Publication status	E-pub ahead of print - 20 Sept 2024

Bibliographical note

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10.1039/d4cc04514a

Binder3-chemcomm
© The Royal Society of Chemistry 2024. This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy.
Accepted author manuscript, 14 MBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
Davies, G. J. (Principal investigator)
EUROPEAN COMMISSION
1/06/21 → 31/05/27
Project: Research project (funded) › Research
RS Research Professorship
Davies, G. J. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 31/12/26
Project: Research project (funded) › Research
X-ray Diffraction Equipment for Macromolecular Crystallography at York
Davies, G. J. (Principal investigator), Antson, A. A. (Co-investigator), Brzozowski, A. M. (Co-investigator), Cowtan, K. (Co-investigator), Fascione, M. A. (Co-investigator), Grogan, G. J. (Co-investigator), Plevin, M. J. (Co-investigator), Thomas, G. H. (Co-investigator), Wilkinson, A. J. (Co-investigator), Willems, L. I. (Co-investigator) & Wilson, K. S. (Co-investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
18/09/20 → 17/09/22
Project: Research project (funded) › Research

Cite this

@article{abe819bb0d774c999d0d2491118e3fe7,

title = "Structure-Guided Design of C3-Branched Swainsonine as Potent and Selective Human Golgi α-Mannosidase (GMII) Inhibitor",

author = "Tony Koemans and Megan Bennett and Ferraz, {Maria J.} and Zachary Armstrong and Marta Artola and Aerts, {Johannes M. F. G.} and Cod{\'e}e, {Jeroen D. C.} and Overkleeft, {Herman S.} and Davies, {Gideon J.}",

note = "{\textcopyright} The Royal Society of Chemistry 2024. This is an author-produced version of the published paper. Uploaded in accordance with the University{\textquoteright}s Research Publications and Open Access policy.",

year = "2024",

month = sep,

day = "20",

doi = "10.1039/d4cc04514a",

language = "English",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "The Royal Society of Chemistry",

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T1 - Structure-Guided Design of C3-Branched Swainsonine as Potent and Selective Human Golgi α-Mannosidase (GMII) Inhibitor

AU - Koemans, Tony

AU - Bennett, Megan

AU - Ferraz, Maria J.

AU - Armstrong, Zachary

AU - Artola, Marta

AU - Aerts, Johannes M. F. G.

AU - Codée, Jeroen D. C.

AU - Overkleeft, Herman S.

AU - Davies, Gideon J.

N1 - © The Royal Society of Chemistry 2024. This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy.

PY - 2024/9/20

Y1 - 2024/9/20

U2 - 10.1039/d4cc04514a

DO - 10.1039/d4cc04514a

M3 - Article

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Structure-Guided Design of C3-Branched Swainsonine as Potent and Selective Human Golgi α-Mannosidase (GMII) Inhibitor

Bibliographical note

Access to Document

Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

X-ray Diffraction Equipment for Macromolecular Crystallography at York

Cite this