Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

Wendy A. Offen; David L. Zechel; Stephen G. Withers; Harry J. Gilbert; Gideon J. Davies

doi:10.1039/b902240f

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

Wendy A. Offen, David L. Zechel, Stephen G. Withers, Harry J. Gilbert, Gideon J. Davies

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The Michaelis complex of the beta-mannosidase Man2A shows distortion to a S-1(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.

Original language	English
Pages (from-to)	2484-2486
Number of pages	3
Journal	Chemical Communications
Issue number	18
DOIs	https://doi.org/10.1039/b902240f
Publication status	Published - 2009

Keywords

SELECTIVE-INHIBITION
TRANSITION-STATE
MECHANISM
GLYCOSIDASES
MANNOSTATIN

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10.1039/b902240f

Cite this

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title = "Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis",

abstract = "The Michaelis complex of the beta-mannosidase Man2A shows distortion to a S-1(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.",

keywords = "SELECTIVE-INHIBITION, TRANSITION-STATE, MECHANISM, GLYCOSIDASES, MANNOSTATIN",

author = "Offen, {Wendy A.} and Zechel, {David L.} and Withers, {Stephen G.} and Gilbert, {Harry J.} and Davies, {Gideon J.}",

year = "2009",

doi = "10.1039/b902240f",

language = "English",

pages = "2484--2486",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "The Royal Society of Chemistry",

number = "18",

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T1 - Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

AU - Offen, Wendy A.

AU - Zechel, David L.

AU - Withers, Stephen G.

AU - Gilbert, Harry J.

AU - Davies, Gideon J.

PY - 2009

Y1 - 2009

N2 - The Michaelis complex of the beta-mannosidase Man2A shows distortion to a S-1(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.

AB - The Michaelis complex of the beta-mannosidase Man2A shows distortion to a S-1(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.

KW - SELECTIVE-INHIBITION

KW - TRANSITION-STATE

KW - MECHANISM

KW - GLYCOSIDASES

KW - MANNOSTATIN

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U2 - 10.1039/b902240f

DO - 10.1039/b902240f

M3 - Article

SN - 1359-7345

SP - 2484

EP - 2486

JO - Chemical Communications

JF - Chemical Communications

IS - 18

ER -

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

Abstract

Keywords

Access to Document

Other files and links

Dissection of alpha mannosidases from reaction corodinate to inhibition

Cite this

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

Abstract

Keywords

Access to Document

Other files and links

Projects

Dissection of alpha mannosidases from reaction corodinate to inhibition

Cite this