Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases

Victoria A. Money, Nicola L. Smith, Adrian Scaffidi, Robert V. Stick, Harry J. Gilbert, Gideon J. Davies

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)5136-5140
Number of pages5
JournalAngewandte Chemie International Edition
Volume45
Issue number31
DOIs
Publication statusPublished - 2006

Keywords

  • drug design
  • enzyme models
  • glycosides
  • reaction pathways
  • transition states
  • ALPHA-MANNOSIDASE-II
  • TRANSITION-STATE
  • CATALYSIS
  • INHIBITION
  • MECHANISM
  • GLUCOSIDASES
  • HYDROLYSIS
  • SNAPSHOTS
  • INSIGHTS

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