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From the same journal

Substrate scope in the copper-mediated construction of bis-oxindoles via a double C-H/Ar-H coupling process

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Publication details

DatePublished - 30 Sep 2015
Issue number39
Number of pages13
Pages (from-to)7124-7136
Original languageEnglish


Abstract The synthesis of bis-oxindoles via the copper(II)-mediated double cyclisation of linear bis-anilides is described. Cu(OAc)<inf>2</inf>·H<inf>2</inf>O was identified as an efficient and inexpensive catalyst for this process. In contrast to previous methods, which rely on the synthesis of the central core from existing oxindole building blocks, this new approach focusses on concurrent formation of both oxindole rings from a simple linear precursor, allowing the formation of bis-oxindoles containing a diverse range of cyclic and acyclic linkers using a single synthetic method.

    Research areas

  • Bis-oxindoles, C-H Functionalisation, Copper

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