Supramolecular complexes of spin-labelled cyclodextrins

Victor Chechik; Gabriela Ionita

doi:10.1039/b607676a

Supramolecular complexes of spin-labelled cyclodextrins

Victor Chechik, Gabriela Ionita

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

EPR spectra of cyclodextrins labelled with TEMPO derivatives (SL-CDs) are sensitive to complexation with large guest molecules. We used SL-CDs to explore the behaviour of concentrated PEG/PPG solutions. The relationship between rotational correlation times and solvent viscosity showed significant deviations from the Debye - Stokes - Einstein equation, probably due to self-aggregation of alkylene glycols in concentrated solutions. The data fit the fractional Debye - Stokes - Einstein equation well. We have also studied complexation of SL-CDs with adamantane-functionalised DAB dendrimers. The strength of binding increases with dendrimer generation; formation of supramolecular aggregates at high concentrations was observed with the generation 3 dendrimer.

Original language	English
Pages (from-to)	3505-3510
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	4
Issue number	18
DOIs	https://doi.org/10.1039/b607676a
Publication status	Published - 2006

Keywords

POLY(ETHYLENE OXIDE)
INCLUSION COMPLEXES
BETA-CYCLODEXTRIN
AQUEOUS-SOLUTIONS
ROTATIONAL DIFFUSION
BIMODAL INCLUSION
RESONANCE
WATER
SUPEROXIDE
MOLECULES

Access to Document

10.1039/b607676a

Cite this

@article{87778525524a4cc0bfcb281301578417,

title = "Supramolecular complexes of spin-labelled cyclodextrins",

abstract = "EPR spectra of cyclodextrins labelled with TEMPO derivatives (SL-CDs) are sensitive to complexation with large guest molecules. We used SL-CDs to explore the behaviour of concentrated PEG/PPG solutions. The relationship between rotational correlation times and solvent viscosity showed significant deviations from the Debye - Stokes - Einstein equation, probably due to self-aggregation of alkylene glycols in concentrated solutions. The data fit the fractional Debye - Stokes - Einstein equation well. We have also studied complexation of SL-CDs with adamantane-functionalised DAB dendrimers. The strength of binding increases with dendrimer generation; formation of supramolecular aggregates at high concentrations was observed with the generation 3 dendrimer.",

keywords = "POLY(ETHYLENE OXIDE), INCLUSION COMPLEXES, BETA-CYCLODEXTRIN, AQUEOUS-SOLUTIONS, ROTATIONAL DIFFUSION, BIMODAL INCLUSION, RESONANCE, WATER, SUPEROXIDE, MOLECULES",

author = "Victor Chechik and Gabriela Ionita",

year = "2006",

doi = "10.1039/b607676a",

language = "English",

volume = "4",

pages = "3505--3510",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "The Royal Society of Chemistry",

number = "18",

}

TY - JOUR

T1 - Supramolecular complexes of spin-labelled cyclodextrins

AU - Chechik, Victor

AU - Ionita, Gabriela

PY - 2006

Y1 - 2006

N2 - EPR spectra of cyclodextrins labelled with TEMPO derivatives (SL-CDs) are sensitive to complexation with large guest molecules. We used SL-CDs to explore the behaviour of concentrated PEG/PPG solutions. The relationship between rotational correlation times and solvent viscosity showed significant deviations from the Debye - Stokes - Einstein equation, probably due to self-aggregation of alkylene glycols in concentrated solutions. The data fit the fractional Debye - Stokes - Einstein equation well. We have also studied complexation of SL-CDs with adamantane-functionalised DAB dendrimers. The strength of binding increases with dendrimer generation; formation of supramolecular aggregates at high concentrations was observed with the generation 3 dendrimer.

AB - EPR spectra of cyclodextrins labelled with TEMPO derivatives (SL-CDs) are sensitive to complexation with large guest molecules. We used SL-CDs to explore the behaviour of concentrated PEG/PPG solutions. The relationship between rotational correlation times and solvent viscosity showed significant deviations from the Debye - Stokes - Einstein equation, probably due to self-aggregation of alkylene glycols in concentrated solutions. The data fit the fractional Debye - Stokes - Einstein equation well. We have also studied complexation of SL-CDs with adamantane-functionalised DAB dendrimers. The strength of binding increases with dendrimer generation; formation of supramolecular aggregates at high concentrations was observed with the generation 3 dendrimer.

KW - POLY(ETHYLENE OXIDE)

KW - INCLUSION COMPLEXES

KW - BETA-CYCLODEXTRIN

KW - AQUEOUS-SOLUTIONS

KW - ROTATIONAL DIFFUSION

KW - BIMODAL INCLUSION

KW - RESONANCE

KW - WATER

KW - SUPEROXIDE

KW - MOLECULES

U2 - 10.1039/b607676a

DO - 10.1039/b607676a

M3 - Article

SN - 1477-0520

VL - 4

SP - 3505

EP - 3510

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 18

ER -