Supramolecular dendrimer chemistry: A journey through the branched architecture

D K  Smith; F  Diederich

Supramolecular dendrimer chemistry: A journey through the branched architecture

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

The three-dimensional branched architecture of a dendrimer consists of three topologically distinct regions: multivalent surface, branching repeat and encapsulated core. This paper discusses the use of dendritic architectures for supramolecular chemistry and, in particular, focuses on the unique ability of the branched shell to affect molecular recognition processes in these three regions. The multivalent nature of the fractal dendrimer surface allows the recognition of multiple guests with maximum efficiency and accessibility. Such multivalent recognition has been used both to enhance binding strengths for weak molecular recognition processes, and also to endow the receptor with much improved guest sensing properties.

With the site of recognition in the branched repeat unit, dendritic hosts can exhibit not only high guest uptake, but also interesting cooperative binding effects. Meanwhile, recognition sites buried at the core experience the unique microenvironment generated by the dendritic branching. This microenvironment can generate new modes of binding and hence novel guest selectivities. As a consequence, such host molecules can mimic aspects of biological behaviour, particularly that of enzymes. Well-defined molecular recognition events with dendritic molecules also provide an entry into more highly organised supramolecular constructions and assemblies. This paper provides a survey of dendritic molecular recognition processes and, in particular, highlights the different ways in which the branched shell can actively control the binding event.

Original language	English
Pages (from-to)	183-227
Number of pages	45
Journal	DENDRIMERS II
Volume	210
Publication status	Published - 2000

Keywords

dendrimer
supramolecular chemistry
molecular recognition
self-assembly
microenvironment
LECTIN-BINDING-PROPERTIES
REDOX-ACTIVE DENDRIMERS
NUCLEIC-ACID DENDRIMERS
IMAGING CONTRAST AGENTS
SOLID-PHASE SYNTHESIS
MOLECULAR RECOGNITION
CASCADE POLYMERS
METALLOPORPHYRIN-DENDRIMERS
ALPHA-THIOSIALODENDRIMERS
CATALYTIC CYCLOPHANES

Cite this

@article{cd05b76093234bee9ff5090c82fcca57,

title = "Supramolecular dendrimer chemistry: A journey through the branched architecture",

abstract = "The three-dimensional branched architecture of a dendrimer consists of three topologically distinct regions: multivalent surface, branching repeat and encapsulated core. This paper discusses the use of dendritic architectures for supramolecular chemistry and, in particular, focuses on the unique ability of the branched shell to affect molecular recognition processes in these three regions. The multivalent nature of the fractal dendrimer surface allows the recognition of multiple guests with maximum efficiency and accessibility. Such multivalent recognition has been used both to enhance binding strengths for weak molecular recognition processes, and also to endow the receptor with much improved guest sensing properties.With the site of recognition in the branched repeat unit, dendritic hosts can exhibit not only high guest uptake, but also interesting cooperative binding effects. Meanwhile, recognition sites buried at the core experience the unique microenvironment generated by the dendritic branching. This microenvironment can generate new modes of binding and hence novel guest selectivities. As a consequence, such host molecules can mimic aspects of biological behaviour, particularly that of enzymes. Well-defined molecular recognition events with dendritic molecules also provide an entry into more highly organised supramolecular constructions and assemblies. This paper provides a survey of dendritic molecular recognition processes and, in particular, highlights the different ways in which the branched shell can actively control the binding event.",

keywords = "dendrimer, supramolecular chemistry, molecular recognition, self-assembly, microenvironment, LECTIN-BINDING-PROPERTIES, REDOX-ACTIVE DENDRIMERS, NUCLEIC-ACID DENDRIMERS, IMAGING CONTRAST AGENTS, SOLID-PHASE SYNTHESIS, MOLECULAR RECOGNITION, CASCADE POLYMERS, METALLOPORPHYRIN-DENDRIMERS, ALPHA-THIOSIALODENDRIMERS, CATALYTIC CYCLOPHANES",

author = "Smith, {D K} and F Diederich",

year = "2000",

language = "English",

volume = "210",

pages = "183--227",

journal = "DENDRIMERS II",

issn = "0342-6793",

}

TY - JOUR

T1 - Supramolecular dendrimer chemistry: A journey through the branched architecture

AU - Smith, D K

AU - Diederich, F

PY - 2000

Y1 - 2000

N2 - The three-dimensional branched architecture of a dendrimer consists of three topologically distinct regions: multivalent surface, branching repeat and encapsulated core. This paper discusses the use of dendritic architectures for supramolecular chemistry and, in particular, focuses on the unique ability of the branched shell to affect molecular recognition processes in these three regions. The multivalent nature of the fractal dendrimer surface allows the recognition of multiple guests with maximum efficiency and accessibility. Such multivalent recognition has been used both to enhance binding strengths for weak molecular recognition processes, and also to endow the receptor with much improved guest sensing properties.With the site of recognition in the branched repeat unit, dendritic hosts can exhibit not only high guest uptake, but also interesting cooperative binding effects. Meanwhile, recognition sites buried at the core experience the unique microenvironment generated by the dendritic branching. This microenvironment can generate new modes of binding and hence novel guest selectivities. As a consequence, such host molecules can mimic aspects of biological behaviour, particularly that of enzymes. Well-defined molecular recognition events with dendritic molecules also provide an entry into more highly organised supramolecular constructions and assemblies. This paper provides a survey of dendritic molecular recognition processes and, in particular, highlights the different ways in which the branched shell can actively control the binding event.

AB - The three-dimensional branched architecture of a dendrimer consists of three topologically distinct regions: multivalent surface, branching repeat and encapsulated core. This paper discusses the use of dendritic architectures for supramolecular chemistry and, in particular, focuses on the unique ability of the branched shell to affect molecular recognition processes in these three regions. The multivalent nature of the fractal dendrimer surface allows the recognition of multiple guests with maximum efficiency and accessibility. Such multivalent recognition has been used both to enhance binding strengths for weak molecular recognition processes, and also to endow the receptor with much improved guest sensing properties.With the site of recognition in the branched repeat unit, dendritic hosts can exhibit not only high guest uptake, but also interesting cooperative binding effects. Meanwhile, recognition sites buried at the core experience the unique microenvironment generated by the dendritic branching. This microenvironment can generate new modes of binding and hence novel guest selectivities. As a consequence, such host molecules can mimic aspects of biological behaviour, particularly that of enzymes. Well-defined molecular recognition events with dendritic molecules also provide an entry into more highly organised supramolecular constructions and assemblies. This paper provides a survey of dendritic molecular recognition processes and, in particular, highlights the different ways in which the branched shell can actively control the binding event.

KW - dendrimer

KW - supramolecular chemistry

KW - molecular recognition

KW - self-assembly

KW - microenvironment

KW - LECTIN-BINDING-PROPERTIES

KW - REDOX-ACTIVE DENDRIMERS

KW - NUCLEIC-ACID DENDRIMERS

KW - IMAGING CONTRAST AGENTS

KW - SOLID-PHASE SYNTHESIS

KW - MOLECULAR RECOGNITION

KW - CASCADE POLYMERS

KW - METALLOPORPHYRIN-DENDRIMERS

KW - ALPHA-THIOSIALODENDRIMERS

KW - CATALYTIC CYCLOPHANES

M3 - Review article

SN - 0342-6793

VL - 210

SP - 183

EP - 227

JO - DENDRIMERS II

JF - DENDRIMERS II

ER -