Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels

Babatunde Okesola; Yuanhao Wu; Burak Derkus; Sammar Gani; Dongsheng Wu; Dafna Knani; David Kelham Smith; Dave Adams; Alvaro Mata

doi:10.1021/acs.chemmater.9b01882

Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels

Babatunde Okesola, Yuanhao Wu, Burak Derkus, Sammar Gani, Dongsheng Wu, Dafna Knani, David Kelham Smith, Dave Adams, Alvaro Mata

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-D-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering (SANS), and molecular dynamics approaches we confirm that the PA undergoes self-sorting while the DBS-gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to the single component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.

Original language	English
Pages (from-to)	7883-7897
Number of pages	15
Journal	Chemistry of Materials
Volume	31
Early online date	12 Sept 2019
DOIs	https://doi.org/10.1021/acs.chemmater.9b01882
Publication status	Published - Oct 2019

Bibliographical note

© 2019 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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10.1021/acs.chemmater.9b01882

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© 2019 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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Cite this

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title = "Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels",

abstract = "Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-D-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering (SANS), and molecular dynamics approaches we confirm that the PA undergoes self-sorting while the DBS-gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to the single component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.",

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AU - Okesola, Babatunde

AU - Wu, Yuanhao

AU - Derkus, Burak

AU - Gani, Sammar

AU - Wu, Dongsheng

AU - Knani, Dafna

AU - Smith, David Kelham

AU - Adams, Dave

AU - Mata, Alvaro

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PY - 2019/10

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N2 - Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-D-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering (SANS), and molecular dynamics approaches we confirm that the PA undergoes self-sorting while the DBS-gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to the single component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.

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