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From the same journal

Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels

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Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels. / Okesola, Babatunde; Wu, Yuanhao; Derkus, Burak; Gani, Sammar; Wu, Dongsheng; Knani, Dafna; Smith, David Kelham; Adams, Dave; Mata, Alvaro.

In: Chemistry of Materials, Vol. 31, 10.2019, p. 7883-7897.

Research output: Contribution to journalArticle

Harvard

Okesola, B, Wu, Y, Derkus, B, Gani, S, Wu, D, Knani, D, Smith, DK, Adams, D & Mata, A 2019, 'Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels', Chemistry of Materials, vol. 31, pp. 7883-7897. https://doi.org/10.1021/acs.chemmater.9b01882

APA

Okesola, B., Wu, Y., Derkus, B., Gani, S., Wu, D., Knani, D., Smith, D. K., Adams, D., & Mata, A. (2019). Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels. Chemistry of Materials, 31, 7883-7897. https://doi.org/10.1021/acs.chemmater.9b01882

Vancouver

Okesola B, Wu Y, Derkus B, Gani S, Wu D, Knani D et al. Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels. Chemistry of Materials. 2019 Oct;31:7883-7897. https://doi.org/10.1021/acs.chemmater.9b01882

Author

Okesola, Babatunde ; Wu, Yuanhao ; Derkus, Burak ; Gani, Sammar ; Wu, Dongsheng ; Knani, Dafna ; Smith, David Kelham ; Adams, Dave ; Mata, Alvaro. / Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels. In: Chemistry of Materials. 2019 ; Vol. 31. pp. 7883-7897.

Bibtex - Download

@article{d5f47dd71e624582bce1ffe4307acf58,
title = "Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels",
abstract = "Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-D-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering (SANS), and molecular dynamics approaches we confirm that the PA undergoes self-sorting while the DBS-gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to the single component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.",
author = "Babatunde Okesola and Yuanhao Wu and Burak Derkus and Sammar Gani and Dongsheng Wu and Dafna Knani and Smith, {David Kelham} and Dave Adams and Alvaro Mata",
note = "{\textcopyright} 2019 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details.",
year = "2019",
month = oct,
doi = "10.1021/acs.chemmater.9b01882",
language = "English",
volume = "31",
pages = "7883--7897",
journal = "Chemistry of Materials",
issn = "0897-4756",
publisher = "American Chemical Society",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Supramolecular Self-Assembly to Control Structural and Biological Properties of Multicomponent Hydrogels

AU - Okesola, Babatunde

AU - Wu, Yuanhao

AU - Derkus, Burak

AU - Gani, Sammar

AU - Wu, Dongsheng

AU - Knani, Dafna

AU - Smith, David Kelham

AU - Adams, Dave

AU - Mata, Alvaro

N1 - © 2019 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2019/10

Y1 - 2019/10

N2 - Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-D-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering (SANS), and molecular dynamics approaches we confirm that the PA undergoes self-sorting while the DBS-gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to the single component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.

AB - Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-D-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering (SANS), and molecular dynamics approaches we confirm that the PA undergoes self-sorting while the DBS-gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to the single component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.

U2 - 10.1021/acs.chemmater.9b01882

DO - 10.1021/acs.chemmater.9b01882

M3 - Article

VL - 31

SP - 7883

EP - 7897

JO - Chemistry of Materials

JF - Chemistry of Materials

SN - 0897-4756

ER -