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Surface-bound antibiotic for the detection of beta-lactamases

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JournalACS applied materials & interfaces
DateAccepted/In press - 25 Jun 2019
DateE-pub ahead of print (current) - 26 Aug 2019
Number of pages6
Early online date26/08/19
Original languageEnglish

Abstract

Antimicrobial resistance (AMR) has been identified as a major threat to public health worldwide. To ensure appropriate use of existing antibiotics, rapid and reliable tests of AMR are necessary. One of the most common and clinically important forms of bacterial resistance is to b-lactam antibiotics (e.g. penicillin). This resistance is often caused by b-lactamases, which hydrolyze b-lactam drugs, rendering them ineffective. Current methods for detecting these enzymes either require time- consuming growth assays or antibiotic mimics such as nitrocefin. Here, we report the development of a surface-bound, clinically- relevant, b-lactam drug that can be used to detect b-lactamases. Furthermore, we demonstrate the use of these functionalized surfaces to selectively detect b-lactamases in complex biological media, such as urine.

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© 2019 American Chemical Society

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