Susceptibility and immunity to helminth parasites

Rick M Maizels; James P Hewitson; Katherine A Smith

doi:10.1016/j.coi.2012.06.003

Susceptibility and immunity to helminth parasites

Rick M Maizels, James P Hewitson, Katherine A Smith

Centre for Immunology and Infection

Research output: Contribution to journal › Article › peer-review

Abstract

Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response. CD4+ Th2 cells then drive a suite of type 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate defence molecules; the concerted effects of these multiple pathways disable, degrade and dislodge parasites, leading to their destruction or expulsion.

Original language	English
Pages (from-to)	459-66
Number of pages	8
Journal	Current opinion in immunology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.coi.2012.06.003
Publication status	Published - Aug 2012

Keywords

Animals
CD4-Positive T-Lymphocytes
Cytokines
Disease Susceptibility
Helminthiasis
Helminths
Humans
Immunity
Th2 Cells

Access to Document

10.1016/j.coi.2012.06.003

Cite this

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title = "Susceptibility and immunity to helminth parasites",

abstract = "Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response. CD4+ Th2 cells then drive a suite of type 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate defence molecules; the concerted effects of these multiple pathways disable, degrade and dislodge parasites, leading to their destruction or expulsion.",

keywords = "Animals, CD4-Positive T-Lymphocytes, Cytokines, Disease Susceptibility, Helminthiasis, Helminths, Humans, Immunity, Th2 Cells",

author = "Maizels, {Rick M} and Hewitson, {James P} and Smith, {Katherine A}",

year = "2012",

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doi = "10.1016/j.coi.2012.06.003",

language = "English",

volume = "24",

pages = "459--66",

journal = "Current opinion in immunology",

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T1 - Susceptibility and immunity to helminth parasites

AU - Maizels, Rick M

AU - Hewitson, James P

AU - Smith, Katherine A

PY - 2012/8

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N2 - Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response. CD4+ Th2 cells then drive a suite of type 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate defence molecules; the concerted effects of these multiple pathways disable, degrade and dislodge parasites, leading to their destruction or expulsion.

AB - Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response. CD4+ Th2 cells then drive a suite of type 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate defence molecules; the concerted effects of these multiple pathways disable, degrade and dislodge parasites, leading to their destruction or expulsion.

KW - Animals

KW - CD4-Positive T-Lymphocytes

KW - Cytokines

KW - Disease Susceptibility

KW - Helminthiasis

KW - Helminths

KW - Humans

KW - Immunity

KW - Th2 Cells

U2 - 10.1016/j.coi.2012.06.003

DO - 10.1016/j.coi.2012.06.003

M3 - Article

C2 - 22795966

SN - 0952-7915

VL - 24

SP - 459

EP - 466

JO - Current opinion in immunology

JF - Current opinion in immunology

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