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Suzuki-Miyaura cross coupling is not an informative reaction to demonstrate the performance of new solvents

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JournalBeilstein Journal of Organic Chemistry
DateAccepted/In press - 4 May 2020
DatePublished (current) - 13 May 2020
Volume16
Number of pages5
Pages (from-to)1001-1005
Original languageEnglish

Abstract

The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki-Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and γ-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of solvent, and therefore the Suzuki-Miyaura reaction provides limited information regarding the usefulness of any particular solvent for organic synthesis.

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© 2020, Sherwood; licensee Beilstein-Institut.

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