Swimming against the tide: progress and challenges in our understanding of colicin translocation

Colin Kleanthous

doi:10.1038/nrmicro2454

Swimming against the tide: progress and challenges in our understanding of colicin translocation

Colin Kleanthous

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Colicins are folded protein toxins that face the formidable task of translocating across one or both of the Escherichia coli cell membranes in order to induce cell death. This translocation is achieved by parasitizing host proteins. There has been much recent progress in our understanding of the early stages of colicin entry, including the binding of outer-membrane nutrient transporters and porins and the subsequent recruitment of periplasmic and inner-membrane proteins that, together, trigger translocation. As well as providing insights into how these toxins enter cells, these studies have highlighted some surprising similarities in the modes of action of the systems that colicins subvert.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	Nature reviews. Microbiology
Volume	8
Issue number	12
DOIs	https://doi.org/10.1038/nrmicro2454
Publication status	Published - Dec 2010

Keywords

ROCK-PAPER-SCISSORS
ESCHERICHIA-COLI
OUTER-MEMBRANE
CRYSTAL-STRUCTURE
IMMUNITY PROTEIN
R-DOMAIN
EVOLUTIONARY RELATIONSHIP
COMPETITIVE RECRUITMENT
RECEPTOR-BINDING
CELL-ENVELOPE

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10.1038/nrmicro2454

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title = "Swimming against the tide: progress and challenges in our understanding of colicin translocation",

abstract = "Colicins are folded protein toxins that face the formidable task of translocating across one or both of the Escherichia coli cell membranes in order to induce cell death. This translocation is achieved by parasitizing host proteins. There has been much recent progress in our understanding of the early stages of colicin entry, including the binding of outer-membrane nutrient transporters and porins and the subsequent recruitment of periplasmic and inner-membrane proteins that, together, trigger translocation. As well as providing insights into how these toxins enter cells, these studies have highlighted some surprising similarities in the modes of action of the systems that colicins subvert.",

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KW - ESCHERICHIA-COLI

KW - OUTER-MEMBRANE

KW - CRYSTAL-STRUCTURE

KW - IMMUNITY PROTEIN

KW - R-DOMAIN

KW - EVOLUTIONARY RELATIONSHIP

KW - COMPETITIVE RECRUITMENT

KW - RECEPTOR-BINDING

KW - CELL-ENVELOPE

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EP - 848

JO - Nature reviews. Microbiology

JF - Nature reviews. Microbiology

IS - 12

ER -

Swimming against the tide: progress and challenges in our understanding of colicin translocation

Abstract

Keywords

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