Synergistic effects in gene delivery - a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Simon P. Jones; Nathan P. Gabrielson; Daniel W. Pack; David K. Smith

doi:10.1039/b811852c

Synergistic effects in gene delivery - a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Simon P. Jones, Nathan P. Gabrielson, Daniel W. Pack, David K. Smith

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

Original language	English
Pages (from-to)	4700-4702
Number of pages	3
Journal	Chemical Communications
Issue number	39
DOIs	https://doi.org/10.1039/b811852c
Publication status	Published - 2008

Keywords

IN-VITRO
CATIONIC LIPIDS
AMPHIPHILIC DENDRIMERS
MULTIVALENT DENDRONS
NONVIRAL CARRIERS
DNA COMPLEXES
THERAPY
VECTORS
FUTURE
EFFICIENCY

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10.1039/b811852c

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title = "Synergistic effects in gene delivery - a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents",

abstract = "Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.",

keywords = "IN-VITRO, CATIONIC LIPIDS, AMPHIPHILIC DENDRIMERS, MULTIVALENT DENDRONS, NONVIRAL CARRIERS, DNA COMPLEXES, THERAPY, VECTORS, FUTURE, EFFICIENCY",

author = "Jones, {Simon P.} and Gabrielson, {Nathan P.} and Pack, {Daniel W.} and Smith, {David K.}",

year = "2008",

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journal = "Chemical Communications",

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publisher = "The Royal Society of Chemistry",

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AU - Gabrielson, Nathan P.

AU - Pack, Daniel W.

AU - Smith, David K.

PY - 2008

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KW - IN-VITRO

KW - CATIONIC LIPIDS

KW - AMPHIPHILIC DENDRIMERS

KW - MULTIVALENT DENDRONS

KW - NONVIRAL CARRIERS

KW - DNA COMPLEXES

KW - THERAPY

KW - VECTORS

KW - FUTURE

KW - EFFICIENCY

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DO - 10.1039/b811852c

M3 - Article

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SP - 4700

EP - 4702

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

Synergistic effects in gene delivery - a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Abstract

Keywords

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