SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF NOJIRIMYCIN

P A  FOWLER; A H  HAINES; R J K  TAYLOR; E J T  CHRYSTAL; M B  GRAVESTOCK

SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF NOJIRIMYCIN

P A FOWLER, A H HAINES, R J K TAYLOR, E J T CHRYSTAL, M B GRAVESTOCK

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.

Original language	English
Pages (from-to)	2229-2235
Number of pages	7
Journal	Journal of the Chemical Society-Perkin Transactions 1
Issue number	16
Publication status	Published - 21 Aug 1994

Keywords

ASYMMETRIC-SYNTHESIS
ALPHA-GLUCOSIDASE
INHIBITORS
ENZYME
DICHROMATE
REAGENTS

Cite this

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title = "SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF NOJIRIMYCIN",

abstract = "A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.",

keywords = "ASYMMETRIC-SYNTHESIS, ALPHA-GLUCOSIDASE, INHIBITORS, ENZYME, DICHROMATE, REAGENTS",

author = "FOWLER, {P A} and HAINES, {A H} and TAYLOR, {R J K} and CHRYSTAL, {E J T} and GRAVESTOCK, {M B}",

year = "1994",

month = aug,

day = "21",

language = "English",

pages = "2229--2235",

journal = "Journal of the Chemical Society-Perkin Transactions 1",

issn = "0300-922X",

publisher = "Chemical Society",

number = "16",

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TY - JOUR

T1 - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF NOJIRIMYCIN

AU - FOWLER, P A

AU - HAINES, A H

AU - TAYLOR, R J K

AU - CHRYSTAL, E J T

AU - GRAVESTOCK, M B

PY - 1994/8/21

Y1 - 1994/8/21

N2 - A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.

AB - A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.

KW - ASYMMETRIC-SYNTHESIS

KW - ALPHA-GLUCOSIDASE

KW - INHIBITORS

KW - ENZYME

KW - DICHROMATE

KW - REAGENTS

M3 - Article

SN - 0300-922X

SP - 2229

EP - 2235

JO - Journal of the Chemical Society-Perkin Transactions 1

JF - Journal of the Chemical Society-Perkin Transactions 1

IS - 16

ER -