Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

Kristian Hollingsworth; Antonio Di Maio; Sarah-Jane Richards; Jean-Baptiste Vendeville; David E. Wheatley; Claire E. Council; Tessa Keenan; Harriet Chidwick; Kun Huang; Fabio Parmeggiani; Andrea Marchesi; Wengang Chai; Ryan McBerney; Tomasz Kaminski; Matthew Balmforth; Alexandra Tamasanu; James Finnigan; Carl Young; Stuart Warriner; Michael E. Webb; Martin Anthony Fascione; S L  Flitsch; M. Carmen Galan; Ten Feizi; Matthew I. Gibson; Yan Liu; W.B. Turnbull; Bruno Linclau

doi:10.1038/s41467-024-51081-7

Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

Kristian Hollingsworth, Antonio Di Maio, Sarah-Jane Richards, Jean-Baptiste Vendeville, David E. Wheatley, Claire E. Council, Tessa Keenan, Harriet Chidwick, Kun Huang, Fabio Parmeggiani, Andrea Marchesi, Wengang Chai, Ryan McBerney, Tomasz Kaminski, Matthew Balmforth, Alexandra Tamasanu, James Finnigan, Carl Young, Stuart Warriner, Michael E. WebbMartin Anthony Fascione, S L Flitsch, M. Carmen Galan, Ten Feizi, Matthew I. Gibson, Yan Liu, W.B. Turnbull, Bruno Linclau

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	7925
Number of pages	14
Journal	Nature Communications
Volume	15
DOIs	https://doi.org/10.1038/s41467-024-51081-7
Publication status	Published - 13 Sept 2024

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10.1038/s41467-024-51081-7Licence: CC BY

Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners
© The Author(s) 2024
Final published version, 2.41 MBLicence: CC BY

Chemo-enzymatic Production of Specialty Glycans
Fascione, M. A. (Principal investigator)
19/10/15 → 18/10/20
Project: Research project (funded) › Research

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Hollingsworth, K., Di Maio, A., Richards, S.-J., Vendeville, J.-B., Wheatley, D. E., Council, C. E., Keenan, T., Chidwick, H., Huang, K., Parmeggiani, F., Marchesi, A., Chai, W., McBerney, R., Kaminski, T., Balmforth, M., Tamasanu, A., Finnigan, J., Young, C., Warriner, S., ... Linclau, B. (2024). Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners. Nature Communications, 15, Article 7925. https://doi.org/10.1038/s41467-024-51081-7

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title = "Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners",

author = "Kristian Hollingsworth and {Di Maio}, Antonio and Sarah-Jane Richards and Jean-Baptiste Vendeville and Wheatley, {David E.} and Council, {Claire E.} and Tessa Keenan and Harriet Chidwick and Kun Huang and Fabio Parmeggiani and Andrea Marchesi and Wengang Chai and Ryan McBerney and Tomasz Kaminski and Matthew Balmforth and Alexandra Tamasanu and James Finnigan and Carl Young and Stuart Warriner and Webb, {Michael E.} and Fascione, {Martin Anthony} and Flitsch, {S L} and Galan, {M. Carmen} and Ten Feizi and Gibson, {Matthew I.} and Yan Liu and W.B. Turnbull and Bruno Linclau",

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doi = "10.1038/s41467-024-51081-7",

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Hollingsworth, K, Di Maio, A, Richards, S-J, Vendeville, J-B, Wheatley, DE, Council, CE, Keenan, T , Chidwick, H, Huang, K, Parmeggiani, F, Marchesi, A, Chai, W, McBerney, R, Kaminski, T, Balmforth, M, Tamasanu, A, Finnigan, J, Young, C, Warriner, S, Webb, ME, Fascione, MA, Flitsch, SL, Galan, MC, Feizi, T, Gibson, MI, Liu, Y, Turnbull, WB & Linclau, B 2024, 'Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners', Nature Communications, vol. 15, 7925. https://doi.org/10.1038/s41467-024-51081-7

TY - JOUR

T1 - Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

AU - Hollingsworth, Kristian

AU - Di Maio, Antonio

AU - Richards, Sarah-Jane

AU - Vendeville, Jean-Baptiste

AU - Wheatley, David E.

AU - Council, Claire E.

AU - Keenan, Tessa

AU - Chidwick, Harriet

AU - Huang, Kun

AU - Parmeggiani, Fabio

AU - Marchesi, Andrea

AU - Chai, Wengang

AU - McBerney, Ryan

AU - Kaminski, Tomasz

AU - Balmforth, Matthew

AU - Tamasanu, Alexandra

AU - Finnigan, James

AU - Young, Carl

AU - Warriner, Stuart

AU - Webb, Michael E.

AU - Fascione, Martin Anthony

AU - Flitsch, S L

AU - Galan, M. Carmen

AU - Feizi, Ten

AU - Gibson, Matthew I.

AU - Liu, Yan

AU - Turnbull, W.B.

AU - Linclau, Bruno

PY - 2024/9/13

Y1 - 2024/9/13

U2 - 10.1038/s41467-024-51081-7

DO - 10.1038/s41467-024-51081-7

M3 - Article

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

M1 - 7925

ER -

Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

Bibliographical note

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Projects

Chemo-enzymatic Production of Specialty Glycans

Cite this