Synthesis of citrate-ciprofloxacin conjugates

Siti R. Md-Saleh; Emily C. Chilvers; Kevin G. Kerr; Stephen J. Milner; Anna M. Snelling; Jan P. Weber; Gavin H. Thomas; Anne-Kathrin Duhme-Klair; Anne Routledge

doi:10.1016/j.bmcl.2009.01.007

Synthesis of citrate-ciprofloxacin conjugates

Siti R. Md-Saleh, Emily C. Chilvers, Kevin G. Kerr, Stephen J. Milner, Anna M. Snelling, Jan P. Weber, Gavin H. Thomas, Anne-Kathrin Duhme-Klair, Anne Routledge

Research output: Contribution to journal › Article › peer-review

Abstract

Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12. (C) 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1496-1498
Number of pages	3
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2009.01.007
Publication status	Published - 1 Mar 2009

Keywords

Ciprofloxacin
Escherichia coli
Citrate
ESCHERICHIA-COLI
QUINOLONE RESISTANCE
OUTER-MEMBRANE
IRON UPTAKE
DNA GYRASE
TRANSPORT
ACCUMULATION
MECHANISMS
CHEMISTRY

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10.1016/j.bmcl.2009.01.007

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title = "Synthesis of citrate-ciprofloxacin conjugates",

abstract = "Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12. (C) 2009 Elsevier Ltd. All rights reserved.",

keywords = "Ciprofloxacin, Escherichia coli, Citrate, ESCHERICHIA-COLI, QUINOLONE RESISTANCE, OUTER-MEMBRANE, IRON UPTAKE, DNA GYRASE, TRANSPORT, ACCUMULATION, MECHANISMS, CHEMISTRY",

author = "Md-Saleh, {Siti R.} and Chilvers, {Emily C.} and Kerr, {Kevin G.} and Milner, {Stephen J.} and Snelling, {Anna M.} and Weber, {Jan P.} and Thomas, {Gavin H.} and Anne-Kathrin Duhme-Klair and Anne Routledge",

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doi = "10.1016/j.bmcl.2009.01.007",

language = "English",

volume = "19",

pages = "1496--1498",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "5",

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TY - JOUR

T1 - Synthesis of citrate-ciprofloxacin conjugates

AU - Md-Saleh, Siti R.

AU - Chilvers, Emily C.

AU - Kerr, Kevin G.

AU - Milner, Stephen J.

AU - Snelling, Anna M.

AU - Weber, Jan P.

AU - Thomas, Gavin H.

AU - Duhme-Klair, Anne-Kathrin

AU - Routledge, Anne

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12. (C) 2009 Elsevier Ltd. All rights reserved.

AB - Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12. (C) 2009 Elsevier Ltd. All rights reserved.

KW - Ciprofloxacin

KW - Escherichia coli

KW - Citrate

KW - ESCHERICHIA-COLI

KW - QUINOLONE RESISTANCE

KW - OUTER-MEMBRANE

KW - IRON UPTAKE

KW - DNA GYRASE

KW - TRANSPORT

KW - ACCUMULATION

KW - MECHANISMS

KW - CHEMISTRY

UR - http://www.scopus.com/inward/record.url?scp=60449091061&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.01.007

DO - 10.1016/j.bmcl.2009.01.007

M3 - Article

SN - 0960-894X

VL - 19

SP - 1496

EP - 1498

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 5

ER -

Synthesis of citrate-ciprofloxacin conjugates

Abstract

Keywords

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