Synthesis of cyclic peptide mimetics via the successive ring expansion of lactams

Thomas C Stephens, Mahendar Lodi, Andrew M Steer, Yun Lin, Matthew T Gill, William Paul Unsworth

Research output: Contribution to journalArticlepeer-review


A successive ring expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution. This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.

Original languageEnglish
Pages (from-to)13314-13318
Number of pages5
JournalChemistry : A European Journal
Issue number54
Early online date9 Aug 2017
Publication statusPublished - 27 Sept 2017

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  • Journal Article
  • cyclic peptides
  • lactams
  • medium-sized rings
  • macrocycles
  • ring expansion
  • Cyclization
  • Amino Acids/chemistry
  • Peptoids/chemical synthesis
  • Molecular Conformation
  • Lactams/chemistry
  • Peptides, Cyclic/chemistry

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